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  • Vandenberghe, Rik (author)

F-18-Flutemetamol Amyloid Imaging in Alzheimer Disease and Mild Cognitive Impairment A Phase 2 Trial

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • 2010-08-04
  • Wiley,2010

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:b123ba6a-431c-4bbc-8061-ce6bcac6840a
  • https://lup.lub.lu.se/record/1672533URI
  • https://doi.org/10.1002/ana.22068DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Objective: The most widely studied positron emission tomography ligand for in vivo P-amyloid imaging is C-11-Pittsburgh compound B (C-11-PIB). Its availability, however, is limited by the need for an on-site cyclotron. Validation of the F-18-labeled PIB derivative F-18-flutemetamol could significantly enhance access to this novel technology. Methods: Twenty-seven patients with early-stage clinically probable Alzheimer disease (AD), 20 with amnestic mild cognitive impairment (MCI), and 15 cognitively intact healthy volunteers (HVs) above and 10 HVs below 55 years of age participated. The primary endpoint was the efficacy of blinded visual assessments of F-18-flutemetamol scans in assigning subjects to a raised versus normal uptake category, with clinical diagnosis as the standard of truth (SOT). As secondary objectives, we determined the correlation between the regional standardized uptake value ratios (SUVRs) for F-18-flutemetamol and its parent molecule C-11-PIB in 20 of the AD subjects and 20 of the MCI patients. We also determined test-retest variability of F-18-flutemetamol SUVRs in 5 of the AD subjects. Results: Blinded visual assessments of F-18-flutemetamol scans assigned 25 of 27 scans from AD subjects and 1 of 15 scans from the elderly HVs to the raised category, corresponding to a sensitivity of 93.1% and a specificity of 93.3% against the SOT. Correlation coefficients between cortical F-18-flutemetamol SUVRs and C-11-PIB SUVRs ranged from 0.89 to 0.92. Test-retest variabilities of regional SUVRs were 1 to 4%. Interpretation: F-18-Flutemetamol performs similarly to the C-11-PIB parent molecule within the same subjects and provides high test-retest replicability and potentially much wider accessibility for clinical and research use. ANN NEUROL 2010;68:319-329

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Van Laere, Koen (author)
  • Ivanoiu, Adrian (author)
  • Salmon, Eric (author)
  • Bastin, Christine (author)
  • Triau, Eric (author)
  • Hasselbalch, Steen (author)
  • Law, Ian (author)
  • Andersen, Allan (author)
  • Korner, Alex (author)
  • Minthon, LennartLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)psyk-lmi (author)
  • Garraux, Gaetan (author)
  • Nelissen, Natalie (author)
  • Bormans, Guy (author)
  • Buckley, Chris (author)
  • Owenius, Rikard (author)
  • Thurfjell, Lennart (author)
  • Farrar, Gill (author)
  • Brooks, David J. (author)
  • Klinisk minnesforskningForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Annals of Neurology: Wiley68:3, s. 319-3291531-82490364-5134

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