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The EffecTs of Amlo...
The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial : Study protocol for a randomised crossover trial
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- Kopczak, Anna (författare)
- University Hospital Munich
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- S Stringer, Michael (författare)
- University of Edinburgh
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- van den Brink, Hilde (författare)
- University Medical Center Utrecht
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- Kerkhofs, Danielle (författare)
- Maastricht University Medical Centre
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- W Blair, Gordon (författare)
- University of Edinburgh
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- van Dinther, Maud (författare)
- Maastricht University Medical Centre
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- Onkenhout, Laurien (författare)
- University Medical Center Utrecht
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- A Wartolowska, Karolina (författare)
- University of Oxford
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- Thrippleton, Michael J. (författare)
- University of Edinburgh
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- Duering, Marco (författare)
- University of Basel,University Hospital Munich
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- Staals, Julie (författare)
- Maastricht University Medical Centre
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Middeke, Martin (författare)
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André, Elisabeth (författare)
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- Norrving, Bo (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Stroke policy och kvalitetsregisterforskning,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Stroke Research Group,Lund University Research Groups,Stroke policy and quality register research,Skåne University Hospital
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- Bousser, Marie Germaine (författare)
- Université Paris Cité
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- Mansmann, Ulrich (författare)
- Ludwig-Maximilian University of Munich
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- Rothwell, Peter M. (författare)
- University of Oxford
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- N Doubal, Fergus (författare)
- University of Edinburgh
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- van Oostenbrugge, Robert (författare)
- Maastricht University Medical Centre
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- Jan Biessels, Geert (författare)
- University Medical Center Utrecht
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- Webb, Alastair J.S. (författare)
- University of Oxford
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- Wardlaw, Joanna M. (författare)
- University of Edinburgh
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- Dichgans, Martin (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,University Hospital Munich
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(creator_code:org_t)
- 2022-12-16
- 2023
- Engelska.
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Ingår i: European Stroke Journal. - : SAGE Publications. - 2396-9873 .- 2396-9881. ; 8:1, s. 387-397
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background: Hypertension is the leading modifiable risk factor for cerebral small vessel diseases (SVDs). Yet, it is unknown whether antihypertensive drug classes differentially affect microvascular function in SVDs. Aims: To test whether amlodipine has a beneficial effect on microvascular function when compared to either losartan or atenolol, and whether losartan has a beneficial effect when compared to atenolol in patients with symptomatic SVDs. Design: TREAT-SVDs is an investigator-led, prospective, open-label, randomised crossover trial with blinded endpoint assessment (PROBE design) conducted at five study sites across Europe. Patients aged 18 years or older with symptomatic SVD who have an indication for antihypertensive treatment and are suffering from either sporadic SVD and a history of lacunar stroke or vascular cognitive impairment (group A) or CADASIL (group B) are randomly allocated 1:1:1 to one of three sequences of antihypertensive treatment. Patients stop their regular antihypertensive medication for a 2-week run-in period followed by 4-week periods of monotherapy with amlodipine, losartan and atenolol in random order as open-label medication in standard dose. Outcomes: The primary outcome measure is cerebrovascular reactivity (CVR) as determined by blood oxygen level dependent brain MRI signal response to hypercapnic challenge with change in CVR in normal appearing white matter as primary endpoint. Secondary outcome measures are mean systolic blood pressure (BP) and BP variability (BPv). Discussion: TREAT-SVDs will provide insights into the effects of different antihypertensive drugs on CVR, BP, and BPv in patients with symptomatic sporadic and hereditary SVDs. Funding: European Union’s Horizon 2020 programme. Trial registration: NCT03082014.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- amlodipine
- antihypertensive drug classes
- blood pressure variability
- CADASIL
- cerebrovascular reactivity
- lacunar stroke
- magnetic resonance imaging
- randomised clinical trial
- Small vessel diseases
- vascular cognitive impairment
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- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Kopczak, Anna
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S Stringer, Mich ...
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van den Brink, H ...
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Kerkhofs, Daniel ...
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W Blair, Gordon
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van Dinther, Mau ...
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visa fler...
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Onkenhout, Lauri ...
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A Wartolowska, K ...
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Thrippleton, Mic ...
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Duering, Marco
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Staals, Julie
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Middeke, Martin
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André, Elisabeth
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Norrving, Bo
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Bousser, Marie G ...
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Mansmann, Ulrich
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Rothwell, Peter ...
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N Doubal, Fergus
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van Oostenbrugge ...
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Jan Biessels, Ge ...
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Webb, Alastair J ...
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Wardlaw, Joanna ...
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Dichgans, Martin
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