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Validation of the m...
Validation of the movement disorder society criteria for the diagnosis of 4-repeat tauopathies
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- Respondek, Gesine (author)
- Technical University of Munich,German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Grimm, Max Joseph (author)
- Technical University of Munich,German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Piot, Ines (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,Technical University of Munich
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- Arzberger, Thomas (author)
- Ludwig-Maximilian University of Munich
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- Compta, Yaroslau (author)
- University of Barcelona
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- Englund, Elisabet (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Ferguson, Leslie W. (author)
- Royal University Hospital, Saskatoon
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- Gelpi, Ellen (author)
- University of Barcelona
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- Roeber, Sigrun (author)
- Ludwig-Maximilian University of Munich
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- Giese, Armin (author)
- Ludwig-Maximilian University of Munich
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- Grossman, Murray (author)
- University of Pennsylvania
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- Irwin, David J. (author)
- University of Pennsylvania
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- Meissner, Wassilios G. (author)
- University of Otago,University of Bordeaux,Groupe Hospitalier Pellegrin
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- Nilsson, Christer (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups
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- Pantelyat, Alexander (author)
- Johns Hopkins University
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- Rajput, Alex (author)
- Royal University Hospital, Saskatoon
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- van Swieten, John C. (author)
- Erasmus University Medical Center
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- Troakes, Claire (author)
- King's College London
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- Höglinger, Günter U. (author)
- Technical University of Munich,German Center for Neurodegenerative Diseases (DZNE), Bonn,Hannover Medical School
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(creator_code:org_t)
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- 2019-09-30
- 2020
- English 6 s.
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In: Movement Disorders. - : Wiley. - 0885-3185 .- 1531-8257. ; 35:1, s. 171-176
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http://dx.doi.org/10...
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https://www.ncbi.nlm...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: The Movement Disorder Society criteria for progressive supranuclear palsy introduced the category “probable 4-repeat (4R)-tauopathy” for joint clinical diagnosis of progressive supranuclear palsy and corticobasal degeneration. Objectives: To validate the accuracy of these clinical criteria for “probable 4R-tauopathy” to predict underlying 4R-tauopathy pathology. Methods: Diagnostic accuracy for 4R-tauopathies according to the established criteria was estimated retrospectively in autopsy-confirmed patients with progressive supranuclear palsy and corticobasal degeneration (grouped as 4R-tauopathies), and Parkinson's disease, multiple system atrophy, and frontotemporal lobar degeneration (grouped as non-4R-tauopathies). Results: We identified 250 cases with progressive supranuclear palsy (N = 195) and corticobasal degeneration (N = 55) and with and non-4R-tauopathies (N = 161). Sensitivity and specificity of “probable 4R-tauopathy” was 10% and 99% in the first year and 59% and 88% at final record. Conclusions: The new diagnostic category “probable 4R-tauopathy” showed high specificity and may be suitable for the recruitment of patients with progressive supranuclear palsy and corticobasal degeneration into therapeutic trials targeting 4R-tauopathy. The low sensitivity underpins the need for diagnostic biomarkers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- corticobasal degeneration
- diagnostic criteria
- Four-repeat tauopathies
- progressive supranuclear palsy
Publication and Content Type
- art (subject category)
- ref (subject category)
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Respondek, Gesin ...
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Grimm, Max Josep ...
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Piot, Ines
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Arzberger, Thoma ...
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Compta, Yaroslau
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Englund, Elisabe ...
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Ferguson, Leslie ...
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Gelpi, Ellen
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Roeber, Sigrun
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Giese, Armin
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Grossman, Murray
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Irwin, David J.
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Meissner, Wassil ...
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Nilsson, Christe ...
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Pantelyat, Alexa ...
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Rajput, Alex
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van Swieten, Joh ...
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Troakes, Claire
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Höglinger, Günte ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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Movement Disorde ...
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Lund University