Leukocyte telomere length predicts SSRI response in major depressive disorder : A preliminary report

Short leukocyte telomere length (LTL) may be associated with several psychiatric disorders, including major depressive disorder (MDD). Short LTL has previously been associated with poor response to psychiatric medications in bipolar disorder and schizophrenia, but no studies have prospectively assessed the relationship of LTL to SSRI response in MDD. We assessed pre-treatment LTL, depression severity (using the Hamilton Depression Rating Scale [HDRS]), and self-reported positive and negative affect in 27 healthy, unmedicated adults with MDD. Subjects then underwent open-label treatment with a selective serotonin reuptake inhibitor (SSRI) antidepressant for eight weeks, after which clinical ratings were repeated. Analyses were corrected for age, sex and BMI. "Non-responders" to treatment (HDRS improvement <50%) had significantly shorter pre-treatment LTL, compared to "Responders" (p=0.037). Further, shorter pre-treatment LTL was associated with less improvement in negative affect (p<0.010) but not with changes in positive affect (p=0.356). This preliminary study is the first to assess the relationship between LTL and SSRI response in MDD and among the first to prospectively assess its relationship to treatment outcome in any psychiatric illness. Our data suggest that short LTL may serve as a vulnerability index of poorer response to SSRI treatment, but this needs examination in larger samples.

Bersani, F SaverioSapienza University of Rome,University of California, San Francisco (författare)
Mellon, Synthia HUniversity of California, San Francisco (författare)
Epel, Elissa SUniversity of California, San Francisco (författare)
Reus, Victor IUniversity of California, San Francisco (författare)
Lindqvist, DanielLund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,University of California, San Francisco(Swepub:lu)med-del (författare)
Reus, Victor I (författare)
Mahan, LauraUniversity of California, San Francisco (författare)
Rosser, RebeccaUniversity of California, San Francisco (författare)
Burke, HeatherUniversity of California, San Francisco (författare)
Coetzee, JohnUniversity of California, San Francisco (författare)
Nelson, J CraigUniversity of California, San Francisco (författare)
Blackburn, Elizabeth HUniversity of California, San Francisco (författare)
Wolkowitz, Owen MUniversity of California, San Francisco (författare)
University of California, San FranciscoSapienza University of Rome (creator_code:org_t)

Av författaren/redakt...: Hough, Christina ...; Bersani, F Saver ...; Mellon, Synthia ...; Epel, Elissa S; Reus, Victor I; Lindqvist, Danie ...; visa fler...; Mahan, Laura; Rosser, Rebecca; Burke, Heather; Coetzee, John; Nelson, J Craig; Blackburn, Eliza ...; Wolkowitz, Owen ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Psykiatri

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