Systematic evaluation of skeletal fractures caused by induction of electroconvulsive seizures in rat state a need for attention and refinement of the procedure

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: id:"swepub:oai:lup.lub.lu.se:b383a0be-929c-49b6-91ab-bb786a21c755" > Systematic evaluati...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Ekemohn, MariaLund University,Lunds universitet,Enheten för psykiatrisk neuromodulering (PNU),Forskargrupper vid Lunds universitet,Psychiatric Neuromodulation Unit (PNU),Lund University Research Groups (author)

Systematic evaluation of skeletal fractures caused by induction of electroconvulsive seizures in rat state a need for attention and refinement of the procedure

Article/chapterEnglish2017

Publisher, publication year, extent ...

2017-04-05
Cambridge University Press (CUP),2017

Numbers

LIBRIS-ID:oai:lup.lub.lu.se:b383a0be-929c-49b6-91ab-bb786a21c755
https://lup.lub.lu.se/record/b383a0be-929c-49b6-91ab-bb786a21c755URI
https://doi.org/10.1017/neu.2017.7DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

Objective: Electroconvulsive therapy (ECT) is one of the most efficient treatments for major depression. Electroconvulsive seizures (ECS), the animal model of ECT, is widely used to study both mechanisms of action and adverse effects of ECT. As the treatment itself serves as an instant anaesthetic and anaesthetic agents may affect memory functions and behaviour, ECS is traditionally administered without muscle relaxation and anaesthesia. A major problem of unmodified ECS, which has only been addressed peripherally in the literature, is that some animals sustain spinal fractures and subsequent hind leg paralysis (paraplegia). This phenomenon leads to a higher degree of suffering and these animals need to be excluded from the studies. To reach sufficient statistical power, the group sizes are therefore often increased and this may lead to a pre-selected study group in risk of skewing the results. Moreover, the study design of the experiments do not comply with the 3R principles, which advocate for both refinement and reduction of animal experiments. The objective of this study is to systematically evaluate injuries caused by ECS. Methods: We summarise the incidence of spinal fractures from 24 studies conducted during 2009–2015 in six different rat strains and report preliminary findings on scapular fractures following auricular ECS. Results: In total, 12.8% of all tested animals suffered from spinal fractures and we find an increase in spinal fracture incidence over time. Furthermore, X-ray analyses revealed that some animals displayed scapular fractures. Conclusion: We discuss consequences of and possible explanations for ECS-induced fractures. Modifications of the method are highly warranted and we furthermore suggest that all animals are thoroughly examined for discrete fractures.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Ortopedi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Orthopaedics hsv//eng
electroconvulsive seizures
rat
skeletal fractures
X-ray

Added entries (persons, corporate bodies, meetings, titles ...)

Kjær Nielsen, MarieAarhus University (author)
Grahm, MatildaLund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-mgm (author)
Tingström, AndersLund University,Lunds universitet,Enheten för psykiatrisk neuromodulering (PNU),Forskargrupper vid Lunds universitet,Psychiatric Neuromodulation Unit (PNU),Lund University Research Groups(Swepub:lu)mpu-ati (author)
Kousholt, BirgitteAarhus University (author)
Wegener, GregersAarhus University (author)
Bay-Richter, CecilieAarhus University(Swepub:lu)med-cbc (author)
Enheten för psykiatrisk neuromodulering (PNU)Forskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

In:Acta Neuropsychiatrica: Cambridge University Press (CUP)29:6, s. 363-3730924-27081601-5215

Internet link

Find in a library

Acta Neuropsychiatrica (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Ekemohn, Maria; Kjær Nielsen, Ma ...; Grahm, Matilda; Tingström, Ander ...; Kousholt, Birgit ...; Wegener, Gregers; show more...; Bay-Richter, Cec ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Orthopaedics

Articles in the publication: Acta Neuropsychi ...

By the university: Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se