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Long-term Risks of ...
Long-term Risks of Depression and Suicide Among Men with Prostate Cancer : A National Cohort Study
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- Edwards, Alexis C. (författare)
- Icahn Sch Med Mt Sinai, Dept Family Med & Community Hlth, New York, NY USA.;Icahn Sch Med Mt Sinai, Dept Family Med, 1 Gustave L Levy Pl, Box 1077, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Dept Community Hlth & Populat Hlth Sci & Policy, 1 Gustave L Levy Pl, Box 1077, New York, NY 10029 USA.,Icahn School of Medicine at Mount Sinai,Virginia Commonwealth University
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- Stattin, Pär (författare)
- Uppsala University,Uppsala universitet,Urologkirurgi
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- Brooks, James D. (författare)
- Stanford Univ, Sch Med, Dept Urol, Stanford, CA USA.,Stanford University School of Medicine
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- Sundquist, Jan (författare)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Family Medicine and Clinical Epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Icahn School of Medicine at Mount Sinai
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- Bill-Axelson, Anna (författare)
- Uppsala University,Uppsala universitet,Institutionen för kirurgiska vetenskaper
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- Edwards, Alexis C. (författare)
- Virginia Commonwealth Univ, Dept Psychiat, Richmond, VA USA.
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- Sundquist, Kristina (författare)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Family Medicine and Clinical Epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Icahn School of Medicine at Mount Sinai
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- Sieh, Weiva (författare)
- Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, New York, NY USA.;Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY USA.,Icahn School of Medicine at Mount Sinai
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Icahn Sch Med Mt Sinai, Dept Family Med & Community Hlth, New York, NY USA;Icahn Sch Med Mt Sinai, Dept Family Med, 1 Gustave L Levy Pl, Box 1077, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Dept Community Hlth & Populat Hlth Sci & Policy, 1 Gustave L Levy Pl, Box 1077, New York, NY 10029 USA. Icahn School of Medicine at Mount Sinai (creator_code:org_t)
- Elsevier BV, 2023
- 2023
- Engelska.
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Ingår i: European Urology. - : Elsevier BV. - 0302-2838 .- 1873-7560. ; 84:3, s. 263-272
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background: A diagnosis of prostate cancer (PC) may cause psychosocial distress that worsens quality of life; however, long-term mental health outcomes are unclear.Objective: To determine the long-term risks of major depression and death by suicide in a large population-based cohort. Design, setting, and participants: This was a national cohort study of 180 189 men diagnosed with PC during 1998-2017 and 1 801 890 age-matched, population-based, control men in Sweden.Outcome measurements and statistical analysis: Major depression and death by suicide were ascertained from nationwide outpatient, inpatient, and death records up to 2018. Cox regression was used to compute hazard ratios (HRs) adjusted for sociodemographic factors and comorbidities. Subanalyses assessed differences by PC treatment during 2005-2017.Results and limitations: Men diagnosed with high-risk PC had higher relative rates of major depression (adjusted HR [aHR] 1.82, 95% confidence interval [CI] 1.75-1.89) and death by suicide (aHR 2.43, 95% CI 2.01-2.95). These associations persisted for >= 10 yr after PC diagnosis. The relative increase in major depression was lower among those treated with radiation (aHR 1.44, 95% CI 1.31-1.57) or surgery (aHR 1.60, 95% CI 1.311.95) in comparison to androgen deprivation therapy (ADT) alone (aHR 2.02, 95% CI 1.89-2.16), whereas the relative rate of suicide death was higher only among those treated solely with ADT (aHR 2.83, 95% CI 1.80-4.43). By contrast, men with low- or intermediate-risk PC had a modestly higher relative rate of major depression (aHR 1.19, 95% CI 1.16-1.23) and higher relative rate of suicide death at 3-12 mo after PC diagnosis (aHR 1.88, 95% CI 1.11-3.18) but not across the entire follow-up period aHR 1.02, 95% CI 0.84-1.25). This study was limited to Sweden and will need replication in other populations.Conclusions: In this large cohort, high-risk PC was associated with substantially higher relative rates of major depression and death by suicide, which persisted for >= 10 yr after PC diagnosis. PC survivors need close follow-up for timely detection and treatment of psychosocial distress. Patient summary: In a large Swedish population, men with aggressive prostate cancer had higher long-term relative rates of depression and suicide. (c) 2023 European Association of Urology. Published by Elsevier B.V. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Depression
- Prostate cancer
- Prostatic neoplasms
- Suicide
- Depression
- Prostate cancer
- Prostatic neoplasms
- Suicide
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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