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  • Reichart, BrunoLudwig-Maximilian University of Munich (author)

Pig-to-non-human primate heart transplantation : The final step toward clinical xenotransplantation?

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • Elsevier BV,2020
  • 7 s.

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  • LIBRIS-ID:oai:lup.lub.lu.se:b43ac76b-aa58-49bb-be89-0033c84c33f1
  • https://lup.lub.lu.se/record/b43ac76b-aa58-49bb-be89-0033c84c33f1URI
  • https://doi.org/10.1016/j.healun.2020.05.004DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: The demand for donated human hearts far exceeds the number available. Xenotransplantation of genetically modified porcine organs provides an alternative. In 2000, an Advisory Board of the International Society for Heart and Lung Transplantation set the benchmark for commencing clinical cardiac xenotransplantation as consistent 60% survival of non-human primates after life-supporting porcine heart transplantations. Recently, we reported the stepwise optimization of pig-to-baboon orthotopic cardiac xenotransplantation finally resulting in consistent success, with 4 recipients surviving 90 (n = 2), 182, and 195 days. Here, we report on 4 additional recipients, supporting the efficacy of our procedure. Results: The first 2 additional recipients succumbed to porcine cytomegalovirus (PCMV) infections on Days 15 and 27, respectively. In 2 further experiments, PCMV infections were successfully avoided, and 3-months survival was achieved. Throughout all the long-term experiments, heart, liver, and renal functions remained within normal ranges. Post-mortem cardiac diameters were slightly increased when compared with that at the time of transplantation but with no detrimental effect. There were no signs of thrombotic microangiopathy. The current regimen enabled the prolonged survival and function of orthotopic cardiac xenografts in altogether 6 of 8 baboons, of which 4 were now added. These results exceed the threshold set by the Advisory Board of the International Society for Heart and Lung Transplantation. Conclusions: The results of our current and previous experimental cardiac xenotransplantations together fulfill for the first time the pre-clinical efficacy suggestions. PCMV-positive donor animals must be avoided.

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  • Längin, MatthiasUniversity Hospital Munich (author)
  • Radan, JuliaLudwig-Maximilian University of Munich (author)
  • Mokelke, MarenLudwig-Maximilian University of Munich (author)
  • Buttgereit, InesLudwig-Maximilian University of Munich (author)
  • Ying, JiaweiLudwig-Maximilian University of Munich (author)
  • Fresch, Ann KathrinLudwig-Maximilian University of Munich (author)
  • Mayr, TanjaUniversity Hospital Munich (author)
  • Issl, LaraLudwig-Maximilian University of Munich (author)
  • Buchholz, StefanUniversity Hospital Munich (author)
  • Michel, SebastianUniversity Hospital Munich (author)
  • Ellgass, ReinhardUniversity Hospital Munich (author)
  • Mihalj, MaksBern University Hospital (author)
  • Egerer, StefanieLudwig-Maximilian University of Munich (author)
  • Baehr, AndreaLudwig-Maximilian University of Munich (author)
  • Kessler, BarbaraLudwig-Maximilian University of Munich (author)
  • Kemter, ElisabethLudwig-Maximilian University of Munich (author)
  • Kurome, MayukoLudwig-Maximilian University of Munich (author)
  • Zakhartchenko, ValeriLudwig-Maximilian University of Munich (author)
  • Steen, StigLund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Heart and Lung transplantation,Lund University Research Groups,Skåne University Hospital(Swepub:lu)thor-sst (author)
  • Sjöberg, TrygveLund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Heart and Lung transplantation,Lund University Research Groups,Skåne University Hospital(Swepub:lu)thor-tsj (author)
  • Paskevicius, AudriusLund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Heart and Lung transplantation,Lund University Research Groups,Skåne University Hospital(Swepub:lu)thor-apa (author)
  • Krüger, LuiseRobert Koch Institut (author)
  • Fiebig, UweRobert Koch Institut (author)
  • Denner, JoachimRobert Koch Institut (author)
  • Godehardt, Antonia W.Paul Ehrlich Institute (author)
  • Tönjes, Ralf R.Paul Ehrlich Institute (author)
  • Milusev, AnastasiaUniversity of Bern (author)
  • Rieben, RobertUniversity of Bern (author)
  • Sfriso, RiccardoUniversity of Bern (author)
  • Walz, ChristophLudwig-Maximilian University of Munich (author)
  • Kirchner, ThomasLudwig-Maximilian University of Munich (author)
  • Ayares, DavidRevivicor, Inc (author)
  • Lampe, KarenGerman Primate Center (author)
  • Schönmann, UweGerman Primate Center (author)
  • Hagl, ChristianUniversity Hospital Munich (author)
  • Wolf, EckhardLudwig-Maximilian University of Munich (author)
  • Klymiuk, NikolaiLudwig-Maximilian University of Munich (author)
  • Abicht, Jan MichaelUniversity Hospital Munich (author)
  • Brenner, PaoloUniversity Hospital Munich (author)
  • Ludwig-Maximilian University of MunichUniversity Hospital Munich (creator_code:org_t)

Related titles

  • In:Journal of Heart and Lung Transplantation: Elsevier BV39:8, s. 751-7571053-2498

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