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The association bet...
The association between early-life relative telomere length and childhood neurodevelopment
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- Feiler, Marina Oktapodas (författare)
- University of Rochester
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- Patel, Deven (författare)
- National Cancer Institute, USA
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- Li, Huiqi (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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- Meacham, Philip J. (författare)
- University of Rochester
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- Watson, Gene E. (författare)
- University of Rochester
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- Shamlaye, Conrad (författare)
- Ministry of Health, Seychelles
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- Yeates, Alison (författare)
- University of Ulster
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- Broberg, Karin (författare)
- Karolinska Institutet,Karolinska Institute
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- van Wijngaarden, Edwin (författare)
- University of Rochester
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska 6 s.
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Ingår i: NeuroToxicology. - : Elsevier BV. - 0161-813X .- 1872-9711. ; 65, s. 22-27
- Relaterad länk:
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http://dx.doi.org/10...
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https://europepmc.or...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Purpose: To examine the association between telomere length and neurodevelopment in children. Methods: We examined the relationship between relative telomere length (rTL) and neurodevelopmental outcomes at 9 and 30 months, and 5 years of age in children enrolled in the Seychelles Child Development Study Nutrition Cohort 1 (NC1). Relative telomere length was measured in cord blood and in child blood at age five. Multivariable linear regression examined associations between neurodevelopmental outcomes and rTL adjusting for relevant covariates. Results: Mean rTL was 1.18 at birth and 0.71 at age five. Increased cord blood rTL was associated with better scores on two neurodevelopmental tests, the psychomotor developmental index (β = 4.01; 95% confidence interval (CI) = 0.17, 7.85) at age 30 months, and the Woodcock Johnson test of achievement letter-word score (β = 2.88; CI = 1.21–4.56) at age five. The Woodcock Johnson test of achievement letter-word score remained statistically significant after two outliers were excluded (β = 2.83; CI = 0.69, 4.97); the psychomotor developmental index did not (β = 3.62; CI = −1.28, 8.52). None of the neurodevelopmental outcomes at age five were associated with five-year rTL. Conclusion: Although increased cord blood rTL was associated with better test scores for a few neurodevelopmental outcomes, this study found little consistent evidence of an association between rTL and neurodevelopment. Future studies with a larger sample size, longer follow-up, and other relevant biological markers (e.g. oxidative stress) are needed to clarify the role of rTL in neurodevelopment and its relevance as a potential surrogate measure for oxidative stress in the field of developmental neurotoxicity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Children
- Cognition
- Epidemiology
- Language
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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