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Validation of a Mit...
Validation of a Mitotic Index Cutoff as a Prognostic Marker in Undifferentiated Uterine Sarcomas
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- Hardell, Elin (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Josefson, Sofia (author)
- Karolinska Institute,Karolinska University Hospital
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- Ghaderi, Mehran (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Skeie-Jensen, Tone (author)
- Oslo university hospital
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Westbom-Fremer, Sofia (author)
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Cheek, Elizabeth H. (author)
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Bell, Debra (author)
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Selling, Jonas (author)
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Schoolmeester, John K. (author)
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- Måsbäck, Anna (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Davidson, Ben (author)
- University of Oslo
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- Carlson, Joseph W. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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(creator_code:org_t)
- 2017
- 2017
- English.
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In: American Journal of Surgical Pathology. - 0147-5185 .- 1532-0979. ; 41:9, s. 1231-1237
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http://dx.doi.org/10...
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Abstract
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- Undifferentiated uterine sarcomas (UUS) are a heterogenous group of high-grade mesenchymal tumors. Although these tumors are highly aggressive, a subset of patients may experience long-term survival. These tumors have previously been divided morphologically into uniform and pleomorphic types. A previous study demonstrated that a mitotic index cutoff of 25 mitoses/10 high-power fields (corresponding to 11.16 mitotic figures/mm) could successfully divide tumors into 2 prognostic groups with significantly different overall survival. The goals of the current study were to (1) validate this mitotic index cutoff in an independent, multicenter cohort and (2) explore the prognostic value of the mitotic index groups in relation to other clinicopathologic variables. Cases were included from 3 independent institutions: The Norwegian Radium Hospital, The Mayo Clinic, and Skåne University Hospital. A total of 40 tumors were included after central review. All cases were negative for the YWHAE-FAM22A/B and JAZF1-JJAZ1 translocations. Survival data were available on all patients. In this study, one-third of patients with UUS survived beyond 5 years. The crude (unadjusted) Cox Proportional Hazards model revealed a number of parameters that significantly impacted overall survival, including mitotic index group, patient age, stage, and the presence of tumor necrosis. Classification into the uniform and pleomorphic types was not prognostic. Combining these parameters into an adjusted model revealed that only the mitotic index group and stage were prognostic. On the basis of these findings, it is proposed that UUS be subdivided into “mitogenic” and “not otherwise specified” types.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Hardell, Elin
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Josefson, Sofia
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Ghaderi, Mehran
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Skeie-Jensen, To ...
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Westbom-Fremer, ...
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Cheek, Elizabeth ...
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show more...
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Bell, Debra
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Selling, Jonas
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Schoolmeester, J ...
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Måsbäck, Anna
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Davidson, Ben
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Carlson, Joseph ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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American Journal ...
- By the university
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Lund University
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Karolinska Institutet