Constitutional and somatic deletions of the Williams-Beuren syndrome critical region in Non-Hodgkin Lymphoma

Here, we report and investigate the genomic alterations of two novel cases of Non-Hodgkin Lymphoma (NHL) in children with Williams-Beuren syndrome (WBS), a multisystem disorder caused by 7q11.23 hemizygous deletion. Additionally, we report the case of a child with NHL and a somatic 7q11.23 deletion. Although the WBS critical region has not yet been identified as a susceptibility locus in NHL, it harbors a number of genes involved in DNA repair. The high proportion of pediatric NHL reported in WBS is intriguing. Therefore, the role of haploinsufficiency of genes located at 7q11.23 in lymphomagenesis deserves to be investigated.

Quentin, Samuel (author)
Rizzari, Carmelo (author)
Lundin, CatarinaLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)klin-clu (author)
Coliva, Tiziana (author)
Edery, Patrick (author)
Fryssira, Helen (author)
Bermont, Laurent (author)
Ferrand, Christophe (author)
Soulier, Jean (author)
Borg, Christophe (author)
Rohrlich, Pierre-Simon (author)
Avdelningen för klinisk genetikInstitutionen för laboratoriemedicin (creator_code:org_t)

In:Journal of Hematology & Oncology: Springer Science and Business Media LLC71756-8722

By the author/editor: Guenat, David; Quentin, Samuel; Rizzari, Carmelo; Lundin, Catarina; Coliva, Tiziana; Edery, Patrick; show more...; Fryssira, Helen; Bermont, Laurent; Ferrand, Christo ...; Soulier, Jean; Borg, Christophe; Rohrlich, Pierre ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

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