Hyperpolarized MRI, functional MRI, MR spectroscopy and CEST to provide metabolic information in vivo

van Zijl, Peter C. M.Johns Hopkins University School of Medicine,Kennedy Krieger Institute (author)

Access to metabolic information in vivo using magnetic resonance (MR) technologies has generally been the niche of MR spectroscopy (MRS) and spectroscopic imaging (MRSI). Metabolic fluxes can be studied using the infusion of substrates labeled with magnetic isotopes, with the use of hyperpolarization especially powerful. Unfortunately, these promising methods are not yet accepted clinically, where fast, simple, and reliable measurement and diagnosis are key. Recent advances in functional MRI and chemical exchange saturation transfer (CEST) MRI allow the use of water imaging to study oxygen metabolism and tissue metabolite levels. These, together with the use of novel data analysis approaches such as machine learning for all of these metabolic MR approaches, are increasing the likelihood of their clinical translation.

Brindle, KevinUniversity of Cambridge (author)
Lu, HanzhangKennedy Krieger Institute,Johns Hopkins University School of Medicine (author)
Barker, Peter B.Johns Hopkins University School of Medicine,Kennedy Krieger Institute (author)
Edden, RichardJohns Hopkins University School of Medicine,Kennedy Krieger Institute (author)
Yadav, NirbhayKennedy Krieger Institute,Johns Hopkins University School of Medicine (author)
Knutsson, LindaLund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,MR Physics,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Johns Hopkins University School of Medicine(Swepub:lu)rafy-lan (author)
Johns Hopkins University School of MedicineKennedy Krieger Institute (creator_code:org_t)

By the author/editor: van Zijl, Peter ...; Brindle, Kevin; Lu, Hanzhang; Barker, Peter B.; Edden, Richard; Yadav, Nirbhay; show more...; Knutsson, Linda; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Radiology Nuclea ...

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