SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Li Yanchun)
 

Sökning: WFRF:(Li Yanchun) > Acid suppressants u...

  • Ma, YueTianjin Medical University (författare)

Acid suppressants use and risk of atherosclerotic cardiovascular disease in middle-aged and older adults

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2022
  • 8 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:b56c7080-3b43-4c58-b61b-6a5cc88cc56c
  • https://lup.lub.lu.se/record/b56c7080-3b43-4c58-b61b-6a5cc88cc56cURI
  • https://doi.org/10.1016/j.atherosclerosis.2022.09.001DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Background and aims: Concerns regarding adverse events associated with the use of acid suppressants have increased. However, the impact of proton pump inhibitors (PPIs) and histamine‐2 receptor antagonists (H2RAs) on the risk of atherosclerotic cardiovascular disease (ASCVD) remains unknown. This study aimed to estimate the risk of ASCVD in association with the use of PPIs and H2RAs. Methods: This prospective cohort study included participants without cardiovascular diseases or anti-hypertensive treatment at baseline (2006–2010) in the UK Biobank. The outcomes were ASCVD and each subtype (coronary artery disease, myocardial infarction, peripheral artery disease, and ischemic stroke). The association was estimated by Cox proportional-hazards models. Results: Among 316,730 individuals (aged 50–88 years), during a median of 12.5 years of follow-up, we documented 13,503 (4.3%) incident ASCVD. Regular PPIs use was associated with a higher risk of ASCVD (HR: 1.16, 95% CI: 1.09–1.23) and every subtype of ASCVD. Among each type of PPIs, omeprazole (HR: 1.19, 95% CI: 1.11–1.28), lansoprazole (HR: 1.11, 95% CI: 1.02–1.22), and pantoprazole (HR: 1.40, 95% CI: 1.00–1.97) were associated with a higher risk of ASCVD. Stratification analysis showed that PPIs use was associated with a higher risk of ASCVD among individuals without indications of medications for PPIs. In addition, use of H2RAs was not related to the risk of ASCVD (HR: 0.97, 95% CI: 0.85–1.11). Conclusions: PPIs were associated with increased risk of ASCVD, particularly amongst participants without indications for medication. Our findings are of important practical significance and suggest that clinicians should be cautious in prophylactic use of PPIs.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Li, ShuTianjin university of traditional chinese medicine (författare)
  • Yang, HongxiTianjin Medical University (författare)
  • Zhang, YuanTianjin Medical University (författare)
  • Li, HuipingLund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups,Tianjin Medical University(Swepub:lu)hu0881li (författare)
  • Zhou, LihuiTianjin Medical University (författare)
  • Lin, JingTianjin Medical University (författare)
  • Chen, YanchunTianjin Medical University (författare)
  • Hou, YabingTianjin Medical University (författare)
  • Zhang, XinyuTianjin Medical University (författare)
  • Liu, Tong (författare)
  • Zhou, XinTianjin Medical University (författare)
  • Wang, YaogangTianjin Medical University,Tianjin university of traditional chinese medicine (författare)
  • Tianjin Medical UniversityTianjin university of traditional chinese medicine (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Atherosclerosis: Elsevier BV358, s. 47-540021-9150

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy