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Serotonin-stimulate...
Serotonin-stimulated phosphoinositide hydrolysis in platelets from post-withdrawal alcoholics
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- Simonsson, Per (författare)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups
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- Berglund, Mats (författare)
- Lund University,Lunds universitet,Kliniskt Centrum för Hälsofrämjande Vård,Forskargrupper vid Lunds universitet,Clinical Health Promotion Centre,Lund University Research Groups
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Oreland, Lars (författare)
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Moberg, Anne-Louise (författare)
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- Alling, Christer (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine
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(creator_code:org_t)
- 1992
- 1992
- Engelska.
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Ingår i: Alcohol and Alcoholism. - 1464-3502. ; 27:6, s. 607-612
- Relaterad länk:
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http://alcalc.oxford...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- It has previously been reported that serotonin-stimulated second messenger formation is inhibited in platelets from alcoholics undergoing detoxification. Serotonin-stimulated signal transduction was therefore analysed in platelets from young post-withdrawal alcoholics to elucidate whether the previously reported inhibition is a state or trait marker of alcoholism. No difference between post-withdrawal alcoholics and controls was found with regard to serotonin-stimulated [32P]-phosphatidylinositol 4,5-bisphosphate hydrolysis or [32P]-phosphatidic acid formation. The results indicate that the inhibited serotonin2 receptor function seen in alcoholics undergoing detoxification is a state-dependent rather than a trait-dependent marker.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Beroendelära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Substance Abuse (hsv//eng)
Publikations- och innehållstyp
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- ref (ämneskategori)
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