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Survival-associated...
Survival-associated heterogeneity of marker-defined perivascular cells in colorectal cancer
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- Mezheyeuski, Artur (författare)
- Karolinska Institutet,Karolinska Institute,Belarusian State Medical University,Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.;Belarusian State Med Univ, Dept Pathol, Minsk, Byelarus.
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- Bradic Lindh, Maja (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.
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- Guren, Tormod Kyrre (författare)
- Oslo university hospital,Oslo Univ Hosp, Dept Oncol, Oslo, Norway.;Oslo Univ Hosp, KG Jebsen Colorectal Canc Res Ctr, Oslo, Norway.
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- Dragomir, Anca (författare)
- Uppsala universitet,Uppsala University,Klinisk och experimentell patologi,Fredrik Pontén
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- Pfeiffer, Per (författare)
- University of Southern Denmark,Univ Southern Denmark, Dept Oncol, Odense, Denmark.
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- Kure, Elin H (författare)
- Oslo university hospital,Oslo Univ Hosp, Inst Canc Res, Dept Canc Genet, Oslo, Norway.
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- Ikdahl, Tone (författare)
- Akershus University Hospital,Akershus Univ Hosp, Lorenskog, Norway.
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- Skovlund, Eva (författare)
- Oslo university hospital,Univ Oslo, Sch Pharm, Oslo, Norway.;Norwegian Inst Publ Hlth, Oslo, Norway.
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- Corvigno, Sara (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.
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- Strell, Carina (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.
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- Pietras, Kristian (författare)
- Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Lund Univ, Div Translat Canc Res, Lund, Sweden.
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- Ponten, Fredrik (författare)
- Uppsala universitet,Uppsala University,Klinisk och experimentell patologi,Fredrik Pontén
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- Mulder, Jan (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Sci Life Lab, Dept Neurosci, Stockholm, Sweden.
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- Qvortrup, Camilla (författare)
- University of Southern Denmark,Univ Southern Denmark, Dept Oncol, Odense, Denmark.
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- Portyanko, Anna (författare)
- Belarusian State Medical University,Belarusian State Med Univ, Dept Pathol, Minsk, Byelarus.
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- Tveit, Kjell Magne (författare)
- Oslo university hospital,Oslo Univ Hosp, Dept Oncol, Oslo, Norway.
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- Glimelius, Bengt (författare)
- Uppsala universitet,Uppsala University,Experimentell och klinisk onkologi
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- Sorbye, Halfdan (författare)
- Haukeland University Hospital,Haukeland Hosp, Dept Oncol, Bergen, Norway.
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- Östman, Arne (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.
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(creator_code:org_t)
- 2016-05-26
- 2016
- Engelska 11 s.
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Ingår i: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 7:27, s. 41948-41958
- Relaterad länk:
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http://dx.doi.org/10... (free)
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http://www.oncotarge...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Perivascular cells (PC) were recently implied as regulators of metastasis and immune cell activity. Perivascular heterogeneity in clinical samples, and associations with other tumor features and outcome, remain largely unknown.Here we report a novel method for digital quantitative analyses of vessel characteristics and PC, which was applied to two collections of human metastatic colorectal cancer (mCRC).Initial analyses identified marker-defined subsets of PC, including cells expressing PDGFR-β or α-SMA or both markers. PC subsets were largely independently expressed in a manner unrelated to vessel density and size. Association studies implied specific oncogenic mutations in malignant cells as determinants of PC status. Semi-quantitative and digital-image-analyses-based scoring of the NORDIC-VII cohort identified significant associations between low expression of perivascular PDGFR-α and -β and shorter overall survival. Analyses of the SPCRC cohort confirmed these findings. Perivascular PDGFR-α and -β remained independent factors for survival in multivariate analyses.Overall, our study identified host vasculature and oncogenic status as determinants of tumor perivascular features. Perivascular PDGFR-α and -β were identified as novel independent markers predicting survival in mCRC. The novel methodology should be suitable for similar analyses in other tumor collections.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Nyckelord
- Actins/metabolism
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Combined Chemotherapy Protocols/therapeutic use
- Biomarkers, Tumor/metabolism
- Cohort Studies
- Colorectal Neoplasms/blood supply
- Female
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Multivariate Analysis
- Neoplasm Metastasis
- Pericytes/metabolism
- Receptor, Platelet-Derived Growth Factor alpha/metabolism
- Receptor, Platelet-Derived Growth Factor beta/metabolism
- Young Adult
- PDGFR
- Pathology
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Mezheyeuski, Art ...
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Bradic Lindh, Ma ...
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Guren, Tormod Ky ...
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Dragomir, Anca
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Pfeiffer, Per
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Kure, Elin H
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Ikdahl, Tone
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Skovlund, Eva
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Corvigno, Sara
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Strell, Carina
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Pietras, Kristia ...
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Ponten, Fredrik
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Mulder, Jan
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Qvortrup, Camill ...
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Portyanko, Anna
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Tveit, Kjell Mag ...
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Glimelius, Bengt
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Sorbye, Halfdan
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Östman, Arne
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Oncotarget
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