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A genome-wide assoc...
A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes
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- Meng, Weihua (författare)
- University of Dundee
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- Shah, Kaanan P. (författare)
- University of Chicago
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- Pollack, Samuela (författare)
- Boston University
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- Toppila, Iiro (författare)
- University of Helsinki,Helsinki University Central Hospital
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- Hebert, Harry L. (författare)
- University of Dundee
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- McCarthy, Mark I. (författare)
- University of Oxford,Wellcome Trust Centre for Human Genetics,Churchill Hospital
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- Groop, Leif (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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- Ahlqvist, Emma (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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- Lyssenko, Valeriya (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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- Agardh, Elisabet (författare)
- Lund University,Lunds universitet,Oftalmologi (Malmö),Forskargrupper vid Lunds universitet,Ophthalmology (Malmö),Lund University Research Groups
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- Daniell, Mark (författare)
- Royal Melbourne Hospital
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- Kaidonis, Georgia (författare)
- Flinders University
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- Craig, Jamie E. (författare)
- Flinders University
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- Mitchell, Paul (författare)
- University of Sydney
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- Liew, Gerald (författare)
- University of Sydney
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- Kifley, Annette (författare)
- University of Sydney
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- Wang, Jie Jin (författare)
- University of Sydney
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- Christiansen, Mark W. (författare)
- Washington University School of Medicine
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- Jensen, Richard A. (författare)
- Washington University School of Medicine
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- Penman, Alan (författare)
- University of Mississippi Medical Center
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- Hancock, Heather A. (författare)
- University of Mississippi Medical Center
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- Chen, Ching J. (författare)
- University of Mississippi Medical Center
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- Correa, Adolfo (författare)
- University of Mississippi Medical Center
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- Kuo, Jane Z. (författare)
- University of California, Los Angeles,CardioDx Inc.
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- Li, Xiaohui (författare)
- University of California, Los Angeles
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- Chen, Yii der I. (författare)
- University of California, Los Angeles
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- Rotter, Jerome I. (författare)
- University of California, Los Angeles
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- Klein, Ronald (författare)
- University of Wisconsin-Madison
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Klein, Barbara (författare)
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- Wong, Tien Y. (författare)
- National University of Singapore
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- Morris, Andrew D. (författare)
- University of Edinburgh
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- Doney, Alexander S.F. (författare)
- University of Dundee
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- Colhoun, Helen M. (författare)
- University of Edinburgh
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- Price, Alkes L. (författare)
- Boston University
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- Burdon, Kathryn P. (författare)
- University of Tasmania,Flinders University
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- Groop, Per Henrik (författare)
- Helsinki University Central Hospital,Monash University,University of Helsinki
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- Sandholm, Niina (författare)
- Helsinki University Central Hospital,University of Helsinki
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- Grassi, Michael A. (författare)
- University of Illinois at Chicago
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- Sobrin, Lucia (författare)
- Harvard Medical School
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- Palmer, Colin N.A. (författare)
- University of Dundee
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- 2018-09-04
- 2018
- Engelska.
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Ingår i: Acta Ophthalmologica. - : Wiley. - 1755-375X. ; 96:7, s. 811-819
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://onlinelibrar...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Purpose: Diabetic retinopathy is the most common eye complication in patients with diabetes. The purpose of this study is to identify genetic factors contributing to severe diabetic retinopathy. Methods: A genome-wide association approach was applied. In the Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) datasets, cases of severe diabetic retinopathy were defined as type 2 diabetic patients who were ever graded as having severe background retinopathy (Level R3) or proliferative retinopathy (Level R4) in at least one eye according to the Scottish Diabetic Retinopathy Grading Scheme or who were once treated by laser photocoagulation. Controls were diabetic individuals whose longitudinal retinopathy screening records were either normal (Level R0) or only with mild background retinopathy (Level R1) in both eyes. Significant Single Nucleotide Polymorphisms (SNPs) were taken forward for meta-analysis using multiple Caucasian cohorts. Results: Five hundred and sixty cases of type 2 diabetes with severe diabetic retinopathy and 4,106 controls were identified in the GoDARTS cohort. We revealed that rs3913535 in the NADPH Oxidase 4 (NOX4) gene reached a p value of 4.05 × 10−9. Two nearby SNPs, rs10765219 and rs11018670 also showed promising p values (p values = 7.41 × 10−8 and 1.23 × 10−8, respectively). In the meta-analysis using multiple Caucasian cohorts (excluding GoDARTS), rs10765219 and rs11018670 showed associations for diabetic retinopathy (p = 0.003 and 0.007, respectively), while the p value of rs3913535 was not significant (p = 0.429). Conclusion: This genome-wide association study of severe diabetic retinopathy suggests new evidence for the involvement of the NOX4 gene.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- diabetes
- diabetic complications
- diabetic retinopathy
- genome-wide association study
- NOX4
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- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Meng, Weihua
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Shah, Kaanan P.
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Pollack, Samuela
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Toppila, Iiro
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Hebert, Harry L.
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McCarthy, Mark I ...
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visa fler...
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Groop, Leif
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Ahlqvist, Emma
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Lyssenko, Valeri ...
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Agardh, Elisabet
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Daniell, Mark
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Kaidonis, Georgi ...
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Craig, Jamie E.
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Mitchell, Paul
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Liew, Gerald
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Kifley, Annette
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Wang, Jie Jin
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Christiansen, Ma ...
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Jensen, Richard ...
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Penman, Alan
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Hancock, Heather ...
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Chen, Ching J.
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Correa, Adolfo
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Kuo, Jane Z.
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Li, Xiaohui
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Chen, Yii der I.
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Rotter, Jerome I ...
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Klein, Ronald
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Klein, Barbara
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Wong, Tien Y.
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Morris, Andrew D ...
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Doney, Alexander ...
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Colhoun, Helen M ...
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Price, Alkes L.
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Burdon, Kathryn ...
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Groop, Per Henri ...
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Sandholm, Niina
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Grassi, Michael ...
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Sobrin, Lucia
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Palmer, Colin N. ...
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