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  • Aglago, Elom K.International Agency for Research on Cancer, World Health Organization (författare)

Consumption of Fish and Long-chain n-3 Polyunsaturated Fatty Acids Is Associated With Reduced Risk of Colorectal Cancer in a Large European Cohort

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2020

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:b680c9c8-95d9-446e-881d-9f686830f1f0
  • https://lup.lub.lu.se/record/b680c9c8-95d9-446e-881d-9f686830f1f0URI
  • https://doi.org/10.1016/j.cgh.2019.06.031DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-162704URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Background & Aims: There is an unclear association between intake of fish and long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFAs) and colorectal cancer (CRC). We examined the association between fish consumption, dietary and circulating levels of n-3 LC-PUFAs, and ratio of n-6:n-3 LC-PUFA with CRC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Dietary intake of fish (total, fatty/oily, lean/white) and n-3 LC-PUFA were estimated by food frequency questionnaires given to 521,324 participants in the EPIC study; among these, 6291 individuals developed CRC (median follow up, 14.9 years). Levels of phospholipid LC-PUFA were measured by gas chromatography in plasma samples from a sub-group of 461 CRC cases and 461 matched individuals without CRC (controls). Multivariable Cox proportional hazards and conditional logistic regression models were used to calculate hazard ratios (HRs) and odds ratios (ORs), respectively, with 95% CIs. Results: Total intake of fish (HR for quintile 5 vs 1, 0.88; 95% CI, 0.80–0.96; Ptrend = .005), fatty fish (HR for quintile 5 vs 1, 0.90; 95% CI, 0.82–0.98; Ptrend = .009), and lean fish (HR for quintile 5 vs 1, 0.91; 95% CI, 0.83–1.00; Ptrend = .016) were inversely associated with CRC incidence. Intake of total n-3 LC-PUFA (HR for quintile 5 vs 1, 0.86; 95% CI, 0.78–0.95; Ptrend = .010) was also associated with reduced risk of CRC, whereas dietary ratio of n-6:n-3 LC-PUFA was associated with increased risk of CRC (HR for quintile 5 vs 1, 1.31; 95% CI, 1.18–1.45; Ptrend < .001). Plasma levels of phospholipid n-3 LC-PUFA was not associated with overall CRC risk, but an inverse trend was observed for proximal compared with distal colon cancer (Pheterogeneity = .026). Conclusions: In an analysis of dietary patterns of participants in the EPIC study, we found regular consumption of fish, at recommended levels, to be associated with a lower risk of CRC, possibly through exposure to n-3 LC-PUFA. Levels of n-3 LC-PUFA in plasma were not associated with CRC risk, but there may be differences in risk at different regions of the colon.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Huybrechts, IngeInternational Agency for Research on Cancer, World Health Organization (författare)
  • Murphy, NeilInternational Agency for Research on Cancer, World Health Organization (författare)
  • Casagrande, CorinneInternational Agency for Research on Cancer, World Health Organization,Aarhus University (författare)
  • Nicolas, GenevieveInternational Agency for Research on Cancer, World Health Organization (författare)
  • Pischon, TobiasMax Delbrück Center for Molecular Medicine (MDC) (författare)
  • Fedirko, VeronikaEmory University Rollins School of Public Health (författare)
  • Severi, GianlucaUniversity of Paris-Saclay (författare)
  • Boutron-Ruault, Marie ChristineUniversity of Paris-Saclay (författare)
  • Fournier, AgnèsUniversity of Paris-Saclay (författare)
  • Katzke, VerenaGerman Cancer Research Centre (författare)
  • Kühn, TilmanGerman Cancer Research Centre (författare)
  • Olsen, AnjaDanish Cancer Society (författare)
  • Tjønneland, AnneUniversity of Copenhagen,Danish Cancer Society (författare)
  • Dahm, Christina C.Aarhus University (författare)
  • Overvad, KimAarhus University,Aalborg University Hospital (författare)
  • Lasheras, CristinaUniversity of Oviedo (författare)
  • Agudo, AntonioCatalan Institute of Oncology,L'Hospitalet de Llobregat, Barcelona (författare)
  • Sánchez, Maria JoseCIBER Epidemiology and Public Health (CIBERESP),University of Granada (författare)
  • Amiano, PilarBiodonostia Health Research Institute (författare)
  • Huerta, José MariaCIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council (författare)
  • Ardanaz, EvaHealth Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)(Swepub:lu)extLU-05 (författare)
  • Perez-Cornago, AuroraUniversity of Oxford (författare)
  • Trichopoulou, AntoniaNational and Kapodistrian University of Athens,Hellenic Health Foundation, Athens (författare)
  • Karakatsani, AnnaNational and Kapodistrian University of Athens,International Agency for Research on Cancer, World Health Organization,Aalborg University Hospital (författare)
  • Martimianaki, GeorgiaHellenic Health Foundation, Athens (författare)
  • Palli, DomenicoInstitute for Cancer Research, Prevention and Clinical Network (ISPRO) (författare)
  • Pala, ValeriaIstituto Nazionale dei Tumori (författare)
  • Tumino, RosarioCivic and M.P Arezzo Hospital (författare)
  • Naccarati, AlessioItalian Institute for Genomic Medicine (IIGM) (författare)
  • Panico, SalvatoreUniversity of Naples Federico II (författare)
  • Bueno-de-Mesquita, BasNational Institute for Public Health and the Environment (RIVM),University Medical Center Utrecht,University of Malaya,Imperial College London (författare)
  • May, AnneUniversity Medical Center Utrecht (författare)
  • Derksen, Jeroen W.G.University Medical Center Utrecht (författare)
  • Hellstrand, SophieLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)med-sph (författare)
  • Ohlsson, BodilLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)kir-boh (författare)
  • Wennberg, Maria,1974-Umeå universitet,Umeå University,Avdelningen för hållbar hälsa(Swepub:umu)mawe0024 (författare)
  • van Guelpen, BethanyUmeå universitet,Umeå University,Onkologi(Swepub:umu)beyvan99 (författare)
  • Skeie, GuriUiT The Arctic University of Norway, Tromsø (författare)
  • Brustad, MagrittUiT The Arctic University of Norway, Tromsø (författare)
  • Weiderpass, ElisabeteInternational Agency for Research on Cancer, World Health Organization (författare)
  • Cross, Amanda J.Imperial College London (författare)
  • Ward, HeatherImperial College London (författare)
  • Riboli, ElioImperial College London (författare)
  • Norat, TeresaImperial College London (författare)
  • Chajes, VeroniqueInternational Agency for Research on Cancer, World Health Organization (författare)
  • Gunter, Marc J.International Agency for Research on Cancer, World Health Organization (författare)
  • International Agency for Research on Cancer, World Health OrganizationAarhus University (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Clinical Gastroenterology and Hepatology: Elsevier BV18:3, s. 6-6661542-35651542-7714

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