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On the use of the h...
On the use of the healthy lifestyle index to investigate specific disease outcomes
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- Viallon, Vivian (author)
- International Agency for Research On Cancer (IARC-WHO), Lyon, France
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- Freisling, Heinz (author)
- International Agency for Research On Cancer (IARC-WHO), Lyon, France
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- Matta, Komodo (author)
- International Agency for Research On Cancer (IARC-WHO), Lyon, France
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- Nannsen, Anne Østergaard (author)
- Department of Public Health, Aarhus University, Aarhus, Denmark
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- Dahm, Christina C. (author)
- Department of Public Health, Aarhus University, Aarhus, Denmark
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- Tjønneland, Anne (author)
- Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark
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- Eriksen, Anne Kirstine (author)
- Danish Cancer Society Research Center, Copenhagen, Denmark
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- Kaaks, Rudolf (author)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Katzke, Verena A. (author)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Schulze, Matthias B. (author)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
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- Masala, Giovanna (author)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy
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- Tagliabue, Giovanna (author)
- Cancer Registry Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy
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- Simeon, Vittorio (author)
- Unit of Medical Statistics, University “L. Vanvitelli”, Naples, Italy
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- Tumino, Rosario (author)
- Hyblean Association for Epidemiological Research, AIRE–ONLUS, Ragusa, Italy
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- Milani, Lorenzo (author)
- Unit of Cancer Epidemiology, Città Della Salute E Della Scienza University-Hospital, and Center for Cancer Prevention (CPO), Turin, Italy
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- Derksen, Jeroen W. G. (author)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
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- van der Schouw, Yvonne T. (author)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
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- Nøst, Therese Haugdahl (author)
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Trondheim, Norway; Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway
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- Borch, Kristin Benjaminsen (author)
- Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway
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- Sandanger, Torkjel M. (author)
- Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway
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- Quirós, J. Ramón (author)
- Public Health Directorate, Asturias, Spain
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- Rodriguez-Barranco, Miguel (author)
- Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria Ibs.GRANADA, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
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- Bonet, Catalina (author)
- Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, L’Hospitalet de Llobregat, Barcelona, Spain; Nutrition and Cancer Group; Epidemiology, Public Health, Cancer Prevention and Palliative Care Program, Bellvitge Biomedical Research Institute - IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain
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- Aizpurua-Atxega, Amaia (author)
- Sub Directorate for Public Health and Addictions of Gipuzkoa, Ministry of Health of the Basque Government, San Sebastián, Spain; Epidemiology of Chronic and Communicable Diseases Group, Biodonostia Health Research Institute, San Sebastián, Spain
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- Cirera, Lluís (author)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain
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- Guevara, Marcela (author)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
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- Sundström, Björn, 1968- (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Winkvist, Anna (author)
- Umeå universitet,Avdelningen för hållbar hälsa,Department of Internal Medicine and Clinical Nutrition, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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- Heath, Alicia K. (author)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Gunter, Marc J. (author)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Weiderpass, Elisabete (author)
- International Agency for Research On Cancer (IARC-WHO), Lyon, France
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- Johansson, Mattias (author)
- International Agency for Research On Cancer (IARC-WHO), Lyon, France
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- Ferrari, Pietro (author)
- International Agency for Research On Cancer (IARC-WHO), Lyon, France
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(creator_code:org_t)
- Springer Nature, 2024
- 2024
- English.
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In: Scientific Reports. - : Springer Nature. - 2045-2322. ; 14:1
- Related links:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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Abstract
Subject headings
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- The healthy lifestyle index (HLI), defined as the unweighted sum of individual lifestyle components, was used to investigate the combined role of lifestyle factors on health-related outcomes. We introduced weighted outcome-specific versions of the HLI, where individual lifestyle components were weighted according to their associations with disease outcomes. Within the European Prospective Investigation into Cancer and Nutrition (EPIC), we examined the association between the standard and the outcome-specific HLIs and the risk of T2D, CVD, cancer, and all-cause premature mortality. Estimates of the hazard ratios (HRs), the Harrell’s C-index and the population attributable fractions (PAFs) were compared. For T2D, the HR for 1-SD increase of the standard and T2D-specific HLI were 0.66 (95% CI: 0.64, 0.67) and 0.43 (0.42, 0.44), respectively, and the C-index were 0.63 (0.62, 0.64) and 0.72 (0.72, 0.73). Similar, yet less pronounced differences in HR and C-index were observed for standard and outcome-specific estimates for cancer, CVD and all-cause mortality. PAF estimates for mortality before age 80 were 57% (55%, 58%) and 33% (32%, 34%) for standard and mortality-specific HLI, respectively. The use of outcome-specific HLI could improve the assessment of the role of lifestyle factors on disease outcomes, thus enhancing the definition of public health recommendations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Cancer
- Cardiovascular diseases
- Composite score
- Healthy lifestyle index
- Lifestyle factors
- Mortality
- Type 2 diabetes
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Viallon, Vivian
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Freisling, Heinz
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Matta, Komodo
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Nannsen, Anne Øs ...
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Dahm, Christina ...
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Tjønneland, Anne
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show more...
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Eriksen, Anne Ki ...
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Kaaks, Rudolf
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Katzke, Verena A ...
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Schulze, Matthia ...
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Masala, Giovanna
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Tagliabue, Giova ...
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Simeon, Vittorio
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Tumino, Rosario
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Milani, Lorenzo
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Derksen, Jeroen ...
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van der Schouw, ...
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Nøst, Therese Ha ...
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Borch, Kristin B ...
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Sandanger, Torkj ...
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Quirós, J. Ramón
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Rodriguez-Barran ...
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Bonet, Catalina
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Aizpurua-Atxega, ...
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Cirera, Lluís
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Guevara, Marcela
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Sundström, Björn ...
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Winkvist, Anna
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Heath, Alicia K.
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Gunter, Marc J.
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Weiderpass, Elis ...
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Johansson, Matti ...
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Ferrari, Pietro
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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Scientific Repor ...
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Umeå University