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Mineral Crystal Thi...
Mineral Crystal Thickness in Calcified Cartilage and Subchondral Bone in Healthy and Osteoarthritic Human Knees
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- Finnilä, Mikko A J (författare)
- University of Oulu
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- Das Gupta, Shuvashis (författare)
- University of Oulu
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- Turunen, Mikael J (författare)
- University of Eastern Finland
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- Hellberg, Iida (författare)
- University of Oulu
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- Turkiewicz, Aleksandra (författare)
- Lund University,Lunds universitet,Lund OsteoArthritis Division - Clinical Epidemiology Unit,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Lutz-Bueno, Viviane (författare)
- ETH Zürich
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- Folkesson, Elin (författare)
- Lund University
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- Holler, Mirko (författare)
- Paul Scherrer Institute
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- Ali, Neserin (författare)
- Lund University,Lunds universitet,Lund OsteoArthritis Division - Clinical Epidemiology Unit,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Hughes, Velocity (författare)
- Lund University,Lunds universitet,Lund OsteoArthritis Division - Clinical Epidemiology Unit,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Isaksson, Hanna (författare)
- Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,LTH profilområde: Teknik för hälsa,LTH profilområden,Other operations, LTH,Faculty of Engineering, LTH,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,LTH Profile Area: Engineering Health,LTH Profile areas,Faculty of Engineering, LTH
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- Tjörnstrand, Jon (författare)
- Skåne University Hospital
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- Önnerfjord, Patrik (författare)
- Lund University,Lunds universitet,Molekylär skelettbiologi,Forskargrupper vid Lunds universitet,Molecular Skeletal Biology,Lund University Research Groups
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- Guizar-Sicairos, Manuel (författare)
- Paul Scherrer Institute
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- Saarakkala, Simo (författare)
- University of Oulu
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- Englund, Martin (författare)
- Lund University,Lunds universitet,Lund OsteoArthritis Division - Clinical Epidemiology Unit,Forskargrupper vid Lunds universitet,Lund University Research Groups
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(creator_code:org_t)
- 2022-08
- 2022
- Engelska 11 s.
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Ingår i: Journal of Bone and Mineral Research. - : Wiley. - 1523-4681 .- 0884-0431. ; 37:9, s. 1700-1710
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Osteoarthritis (OA) is the most common joint disease, where articular cartilage degradation is often accompanied with sclerosis of the subchondral bone. However, the association between OA and tissue mineralization at the nanostructural level is currently not understood. In particular, it is technically challenging to study calcified cartilage, where relevant but poorly understood pathological processes such as tidemark multiplication and advancement occur. Here, we used state-of-the-art microfocus small-angle X-ray scattering with a 5-μm spatial resolution to determine the size and organization of the mineral crystals at the nanostructural level in human subchondral bone and calcified cartilage. Specimens with a wide spectrum of OA severities were acquired from both medial and lateral compartments of medial compartment knee OA patients (n = 15) and cadaver knees (n = 10). Opposing the common notion, we found that calcified cartilage has thicker and more mutually aligned mineral crystals than adjoining bone. In addition, we, for the first time, identified a well-defined layer of calcified cartilage associated with pathological tidemark multiplication, containing 0.32 nm thicker crystals compared to the rest of calcified cartilage. Finally, we found 0.2 nm thicker mineral crystals in both tissues of the lateral compartment in OA compared with healthy knees, indicating a loading-related disease process because the lateral compartment is typically less loaded in medial compartment knee OA. In summary, we report novel changes in mineral crystal thickness during OA. Our data suggest that unloading in the knee might be involved with the growth of mineral crystals, which is especially evident in the calcified cartilage.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Nyckelord
- ANALYSIS/QUANTITATION OF BONE
- BONE MODELING AND REMODELING
- COLLAGEN
- MATRIX MINERALIZATION
- OSTEOARTHRITIS
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
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Finnilä, Mikko A ...
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Das Gupta, Shuva ...
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Turunen, Mikael ...
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Hellberg, Iida
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Turkiewicz, Alek ...
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Lutz-Bueno, Vivi ...
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visa fler...
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Folkesson, Elin
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Holler, Mirko
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Ali, Neserin
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Hughes, Velocity
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Isaksson, Hanna
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Tjörnstrand, Jon
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Önnerfjord, Patr ...
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Guizar-Sicairos, ...
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Saarakkala, Simo
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Englund, Martin
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Ortopedi
- Artiklar i publikationen
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Journal of Bone ...
- Av lärosätet
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Lunds universitet