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Evaluating the Effe...
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
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- Volz, Erik (author)
- Imperial College London
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- Hill, Verity (author)
- University of Edinburgh
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- McCrone, John T (author)
- University of Edinburgh
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- Price, Anna (author)
- Cardiff Metropolitan University
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Jorgensen, David (author)
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- O'Toole, Áine (author)
- University of Edinburgh
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- Southgate, Joel (author)
- Cardiff Metropolitan University
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Johnson, Robert (author)
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- Jackson, Ben (author)
- University of Edinburgh
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- Nascimento, Fabricia F (author)
- Imperial College London
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- Rey, Sara M (author)
- Public Health Wales
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- Nicholls, Samuel M (author)
- Birmingham City University
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Colquhoun, Rachel M (author)
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- da Silva Filipe, Ana (author)
- University of Glasgow
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- Shepherd, James (author)
- University of Glasgow
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Pascall, David J (author)
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Shah, Rajiv (author)
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Jesudason, Natasha (author)
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Li, Kathy (author)
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Jarrett, Ruth (author)
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- Pacchiarini, Nicole (author)
- Public Health Wales
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Bull, Matthew (author)
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Geidelberg, Lily (author)
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Siveroni, Igor (author)
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- Goodfellow, Ian (author)
- University of Cambridge
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- Loman, Nicholas J (author)
- Birmingham City University
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- Pybus, Oliver G (author)
- University of Oxford
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- Robertson, David L (author)
- University of Glasgow
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Thomson, Emma C (author)
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Rambaut, Andrew (author)
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- Connor, Thomas R (author)
- Cardiff Metropolitan University
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- Balcazar Lopez, Carlos Enrique (creator_code:cre_t)
- Lund University,Lunds universitet,Funktionell bröstcancergenomik,Forskargrupper vid Lunds universitet,Bröst/ovarialcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Functional Breast Cancer Genomics,Lund University Research Groups,Breast/ovarian cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Edinburgh
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(creator_code:org_t)
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- Elsevier BV, 2021
- 2021
- English.
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In: Cell. - : Elsevier BV. - 1097-4172 .- 0092-8674. ; 184:1, s. 11-75
- Related links:
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http://dx.doi.org/10...
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http://www.cell.com/...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Amino Acid Substitution
- Aspartic Acid/analysis
- COVID-19/epidemiology
- Genome, Viral
- Glycine/analysis
- Humans
- Mutation
- SARS-CoV-2/genetics
- Spike Glycoprotein, Coronavirus/genetics
- United Kingdom/epidemiology
- Virulence
- Whole Genome Sequencing
Publication and Content Type
- art (subject category)
- ref (subject category)
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Cell
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- By the author/editor
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Volz, Erik
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Hill, Verity
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McCrone, John T
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Price, Anna
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Jorgensen, David
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O'Toole, Áine
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show more...
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Southgate, Joel
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Johnson, Robert
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Jackson, Ben
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Nascimento, Fabr ...
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Rey, Sara M
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Nicholls, Samuel ...
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Colquhoun, Rache ...
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da Silva Filipe, ...
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Shepherd, James
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Pascall, David J
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Shah, Rajiv
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Jesudason, Natas ...
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Li, Kathy
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Jarrett, Ruth
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Pacchiarini, Nic ...
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Bull, Matthew
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Geidelberg, Lily
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Siveroni, Igor
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Goodfellow, Ian
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Loman, Nicholas ...
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Pybus, Oliver G
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Robertson, David ...
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Thomson, Emma C
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Rambaut, Andrew
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Connor, Thomas R
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Balcazar Lopez, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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Cell
- By the university
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Lund University