Sökning: L773:1749 6632 OR L773:0077 8923 >
Increased autoantib...
Increased autoantibodies to SOX13 in Swedish patients with type 1 diabetes.
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- Törn, Carina (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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Shtauvere-Brameus, A (författare)
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- Sanjeevi, C B (författare)
- Karolinska Institutet
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- Landin-Olsson, Mona (författare)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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(creator_code:org_t)
- Wiley, 2002
- 2002
- Engelska.
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Ingår i: Annals of the New York Academy of Sciences. - : Wiley. - 0077-8923 .- 1749-6632. ; 958, s. 218-223
- Relaterad länk:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- This article aims to estimate the prevalence of SOX13 antibodies in Swedish patients with type 1 diabetes and healthy controls. The patients (n = 102; median age 35 years [range, 9-89]) were newly diagnosed with type 1 diabetes in a defined area in southern Sweden during 1995-1998. Islet cell antibodies (ICA) were analyzed with immunofluorescence, while glutamic acid decarboxylase antibodies (GADA), tyrosine phosphatase antibodies (IA-2A), and antibodies against the transcription factor SOX13 (SOX13Ab) were analyzed with radioimmunoprecipitating assays. SOX13Ab were found in 9.8% (10/102) of type 1 patients compared to 2.0% (2/99) in healthy controls (P = 0.033). At least one of the four autoantibodies (ICA, GADA, IA-2A or SOX13Ab) were identified in 67% (68/102) of the patients. Samples positive for IA-2A were only in one case positive also for SOX13Ab. IA-2A-positive patients were often positive also for ICA and GADA (19/27), and the same combination was also common for SOX13Ab-positive patients (6/10). Only 2.0% (2/102) were positive for SOX13Ab alone. ICA, GADA and IA-2A were more frequent in younger patients (
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Nyckelord
- Diabetes Mellitus
- Child
- Autoantigens : immunology
- Autoantigens : blood
- Autoantibodies : immunology
- Autoantibodies : blood
- Aging : immunology
- 80 and over
- Aged
- Adult
- Adolescence
- High Mobility Group Proteins : blood
- High Mobility Group Proteins : immunology
- Human
- Middle Age
- Support
- Non-U.S. Gov't
- Sweden : epidemiology
- Insulin-Dependent : epidemiology
- Insulin-Dependent : immunology
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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