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  • Törn, CarinaLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups (author)

Increased autoantibodies to SOX13 in Swedish patients with type 1 diabetes.

  • Article/chapterEnglish2002

Publisher, publication year, extent ...

  • Wiley,2002

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:b70deb06-52b3-4814-9a22-45a65523f17b
  • https://lup.lub.lu.se/record/108329URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1928641URI
  • https://doi.org/10.1111/j.1749-6632.2002.tb02973.xDOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • This article aims to estimate the prevalence of SOX13 antibodies in Swedish patients with type 1 diabetes and healthy controls. The patients (n = 102; median age 35 years [range, 9-89]) were newly diagnosed with type 1 diabetes in a defined area in southern Sweden during 1995-1998. Islet cell antibodies (ICA) were analyzed with immunofluorescence, while glutamic acid decarboxylase antibodies (GADA), tyrosine phosphatase antibodies (IA-2A), and antibodies against the transcription factor SOX13 (SOX13Ab) were analyzed with radioimmunoprecipitating assays. SOX13Ab were found in 9.8% (10/102) of type 1 patients compared to 2.0% (2/99) in healthy controls (P = 0.033). At least one of the four autoantibodies (ICA, GADA, IA-2A or SOX13Ab) were identified in 67% (68/102) of the patients. Samples positive for IA-2A were only in one case positive also for SOX13Ab. IA-2A-positive patients were often positive also for ICA and GADA (19/27), and the same combination was also common for SOX13Ab-positive patients (6/10). Only 2.0% (2/102) were positive for SOX13Ab alone. ICA, GADA and IA-2A were more frequent in younger patients (

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  • Shtauvere-Brameus, A (author)
  • Sanjeevi, C BKarolinska Institutet (author)
  • Landin-Olsson, MonaLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-mla (author)
  • Celiaki och diabetesForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Annals of the New York Academy of Sciences: Wiley958, s. 218-2230077-89231749-6632

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