The Association Between Hyperglycemia and Fracture Risk in Middle Age. A prospective, population-based study of 22 444 men and 10 902 women.

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Holmberg, Anna HLund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups (author)

The Association Between Hyperglycemia and Fracture Risk in Middle Age. A prospective, population-based study of 22 444 men and 10 902 women.

Article/chapterEnglish2008

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The Endocrine Society,2008

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LIBRIS-ID:oai:lup.lub.lu.se:b7179574-aa1f-48e2-af8a-4c8c886e6d50
https://lup.lub.lu.se/record/1035365URI
https://doi.org/10.1210/jc.2007-0843DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype

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Aims: Type 1 diabetes mellitus is associated with increased fracture risk, whereas the risk associated with type 2 diabetes is less obvious. Elevated fasting blood glucose (FBG) and high 2-hour glucose during an oral glucose tolerance test (OGTT) indicate impaired glucose tolerance or diabetes. The associations between FBG, 2-h glucose and the risk of fracture were investigated. Methods: The Malmö Preventive Project consists of 22 444 men (44 +/- 6.6 yrs) and 10 902 women (50 +/- 7.4 yrs), with a follow-up of 19 (+/-3.9)years and 15 (+/-4.5) years for incident fractures. Baseline assessment included multiple examinations and lifestyle information. A logistic regression model was used. Adjustments were made for age, BMI, and smoking. Results: Low-energy fractures were recorded in 1246 men and 1236 women. A 2-h glucose measurement between 4.3 and 6.2 mmol/L in men (2(nd) and 3(rd) quartiles), and above 6.5 mmol/L in women (3(rd) and 4(th) quartiles), adjusted for age, BMI, and smoking, was significantly associated with decreased risk of multiple fractures, in men (ORs 0.57-0.71) and women (ORs 0.38-0.66). In women, a 2-h glucose measurement above 7.5 mmol/L was associated with a decreased risk of osteoporotic fractures (OR 0.57, CI 95% 0.44-0.74). Conclusions: In middle-aged men and women, elevated 2-h glucose levels were associated with decreased risks of multiple and osteoporotic fractures, independent of age, BMI, and smoking. A high 2-h glucose level is characterized by peripheral insulin resistance with a high insulin level. Our findings indirectly suggest a positive effect on bone from hyperglycemia.

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MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Ortopedi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Orthopaedics hsv//eng

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Nilsson, P M (author)
Nilsson, Jan-ÅkeLund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups(Swepub:lu)med-jnn (author)
Akesson, KLund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)orto-kak (author)
Ortopedi - klinisk och molekylär osteoporosforskningForskargrupper vid Lunds universitet (creator_code:org_t)

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In:Journal of Clinical Endocrinology and Metabolism: The Endocrine Society93:3, s. 815-8221945-71970021-972X

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By the author/editor: Holmberg, Anna H; Nilsson, P M; Nilsson, Jan-Åke; Akesson, K

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Orthopaedics

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By the university: Lund University

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