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Cyclosporin A incre...
Cyclosporin A increases survival of cross-species intrastriatal grafts of embryonic dopamine-containing neurons
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- Brundin, P (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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- Nilsson, O G (author)
- Lund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Gage, F H (author)
- Lund University
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- Björklund, A (author)
- Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups
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(creator_code:org_t)
- 1985
- 1985
- English 5 s.
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In: Experimental Brain Research. - 0014-4819. ; 60:1, s. 8-204
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http://dx.doi.org/10...
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Abstract
Subject headings
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- The survival and function of cross-species (mouse-to-rat) grafts of fetal mesencephalic dopamine (DA) neurons, implanted as a cell suspension in the striatum of rats with lesions of the mesostriatal DA system, have been studied in animals with and without immunosuppression induced by Cyclosporin A (CyA). At 6 weeks after grafting 3 out of 7 non-CyA treated animals showed some degree of graft survival and variable functional compensation. In those three animals an average of 92 DA neurons per graft was counted. In the grafted animals treated with daily CyA injections, all grafts survived and produced partial or complete functional compensation, and they had an average of 557 DA neurons per graft. It is concluded that intracerebral graft survival and function can be greatly improved by CyA treatment and that the immunological protection of neural transplants in the brain is only partial.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Animals
- Cyclosporins/pharmacology
- Dopamine/physiology
- Female
- Graft Survival/drug effects
- Hydroxydopamines
- Mesencephalon/transplantation
- Mice
- Mice, Inbred A
- Oxidopamine
- Parkinson Disease, Secondary/chemically induced
- Rats
- Rats, Inbred Strains
- Transplantation, Heterologous
Publication and Content Type
- art (subject category)
- ref (subject category)
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