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Early findings in a...
Early findings in a randomised controlled trial on crosslinking protocols using isoosmolar and hypoosmolar riboflavin for the treatment of progressive keratoconus
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- Gustafsson, Ingemar (författare)
- Lund University,Lunds universitet,Klinisk forskning inom hornhinnesjukdomar,Forskargrupper vid Lunds universitet,Clinical research in corneal disease and disorders,Lund University Research Groups,Skåne University Hospital
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- Olafsdottir, Thorbjörg (författare)
- Skåne University Hospital,Lund University
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- Neumann, Olof (författare)
- Lund University,Lunds universitet,Forskargruppen för oftalmologisk avbildning,Forskargrupper vid Lunds universitet,LU profilområde: Ljus och material,Lunds universitets profilområden,Ophthalmology Imaging Research Group,Lund University Research Groups,LU Profile Area: Light and Materials,Lund University Profile areas,Skåne University Hospital
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- Johansson, Per E (författare)
- Lund University,Skåne University Hospital
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- Bizios, Dimitrios (författare)
- Lund University,Lunds universitet,Oftalmologi (Malmö),Forskargrupper vid Lunds universitet,Ophthalmology (Malmö),Lund University Research Groups,Skåne University Hospital
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- Ivarsen, Anders (författare)
- Aarhus University Hospital
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- Hjortdal, Jesper (författare)
- Aarhus University Hospital
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(creator_code:org_t)
- Engelska.
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Ingår i: Acta Ophthalmologica. - 1755-3768. ; , s. 1-10
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- PurposeTo present baseline characteristics and to present the perioperative corneal thickness during corneal crosslinking (CXL) treatment for progressive keratoconus and to describe how the addition of sterile water (SW) efficaciously can maintain the corneal thickness. The treatment efficacy will be evaluated when the 1-year follow-up is complete.MethodsA randomised clinical study using epithelium-off CXL with continuous UVA irradiation (9 mW/cm2) and two kinds of riboflavin solutions: (i) isoosmolar dextran-based riboflavin (n = 27) and (ii) hypoosmolar dextran-free riboflavin (n = 27). Inclusion criteria: progressive keratoconus with an increase in maximum keratometry value (Kmax) of 1.0 dioptre (12 months) or 0.5 dioptres (6 months). Corneae thinner than 400 μm were also included. Outcome parameters: Perioperative corneal thickness and the effect of adding SW.ResultsSeventy-four per cent of the patients in the isoosmolar group and 15% in the hypoosmolar group required the addition of SW, which effectively maintained a corneal thickness of 400 μm in all cases during CXL. The addition of SW was primarily needed during the irradiation procedure and not the preoperative soaking period.ConclusionsEspecially during the CXL irradiation phase, isoosmolar riboflavin causes a significant dehydrating effect leading to corneal thinning during CXL. The customised addition of SW is efficacious in maintaining the corneal thickness during CXL and could increase the safety of the procedure.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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