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Ultra-processed foo...
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Morales-Berstein, FernandaUniversity of Bristol
(author)
Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study : a mediation analysis
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LIBRIS-ID:oai:lup.lub.lu.se:b9982bb4-9c22-471d-9247-43f76bf0aad0
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https://lup.lub.lu.se/record/b9982bb4-9c22-471d-9247-43f76bf0aad0URI
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https://doi.org/10.1007/s00394-023-03270-1DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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PURPOSE: To investigate the role of adiposity in the associations between ultra-processed food (UPF) consumption and head and neck cancer (HNC) and oesophageal adenocarcinoma (OAC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.METHODS: Our study included 450,111 EPIC participants. We used Cox regressions to investigate the associations between the consumption of UPFs and HNC and OAC risk. A mediation analysis was performed to assess the role of body mass index (BMI) and waist-to-hip ratio (WHR) in these associations. In sensitivity analyses, we investigated accidental death as a negative control outcome.RESULTS: During a mean follow-up of 14.13 ± 3.98 years, 910 and 215 participants developed HNC and OAC, respectively. A 10% g/d higher consumption of UPFs was associated with an increased risk of HNC (hazard ratio [HR] = 1.23, 95% confidence interval [CI] 1.14-1.34) and OAC (HR = 1.24, 95% CI 1.05-1.47). WHR mediated 5% (95% CI 3-10%) of the association between the consumption of UPFs and HNC risk, while BMI and WHR, respectively, mediated 13% (95% CI 6-53%) and 15% (95% CI 8-72%) of the association between the consumption of UPFs and OAC risk. UPF consumption was positively associated with accidental death in the negative control analysis.CONCLUSIONS: We reaffirmed that higher UPF consumption is associated with greater risk of HNC and OAC in EPIC. The proportion mediated via adiposity was small. Further research is required to investigate other mechanisms that may be at play (if there is indeed any causal effect of UPF consumption on these cancers).
Subject headings and genre
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Biessy, CarineInternational Agency for Research on Cancer, World Health Organization
(author)
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Viallon, VivianInternational Agency for Research on Cancer, World Health Organization
(author)
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Goncalves-Soares, AnaUniversity of Bristol
(author)
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Casagrande, CorinneInternational Agency for Research on Cancer, World Health Organization
(author)
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Hémon, Bertrand
(author)
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Kliemann, Nathalie
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Cairat, ManonInternational Agency for Research on Cancer, World Health Organization
(author)
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Blanco Lopez, Jessica
(author)
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Al Nahas, Aline
(author)
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Chang, KiaraImperial College London
(author)
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Vamos, EszterImperial College London
(author)
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Rauber, FernandaUniversity of São Paulo
(author)
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Bertazzi Levy, RenataUniversity of São Paulo
(author)
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Barbosa Cunha, DianaState University of Rio de Janeiro
(author)
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Jakszyn, PaulaCatalan Institute of Oncology
(author)
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Ferrari, Pietro
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Vineis, PaoloImperial College London
(author)
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Masala, GiovannaInstitute for Cancer Research, Prevention and Clinical Network (ISPRO)
(author)
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Catalano, AlbertoUniversity of Turin
(author)
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Sonestedt, EmilyLund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups(Swepub:lu)medf-eso
(author)
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Borné, YanLund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups(Swepub:lu)med-boy
(author)
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Katzke, VerenaGerman Cancer Research Centre
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Bajracharya, RashmitaGerman Cancer Research Centre
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Agnoli, Claudia
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Guevara, MarcelaNavarre Public Health Institute (ISPN)
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Heath, AliciaImperial College London
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Radoï, LoredanaUniversity of Paris-Saclay
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Mancini, FrancescaUniversity of Paris-Saclay
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Weiderpass, ElisabeteInternational Agency for Research on Cancer, World Health Organization
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Huerta, José MaríaCIBER Epidemiology and Public Health (CIBERESP)
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Sánchez, María-JoséCIBER Epidemiology and Public Health (CIBERESP)
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Tjønneland, AnneDanish Cancer Society
(author)
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Kyrø, CecilieDanish Cancer Society
(author)
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Schulze, Matthias BGerman Institute of Human Nutrition
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Skeie, GuriUiT The Arctic University of Norway, Tromsø
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Lukic, MarkoUiT The Arctic University of Norway, Tromsø
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Braaten, TonjeUiT The Arctic University of Norway, Tromsø
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Gunter, Marc
(author)
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Millett, ChristopherImperial College London
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Agudo, AntonioCatalan Institute of Oncology
(author)
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Brennan, PaulGerman Cancer Research Centre
(author)
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Borges, M CarolinaUniversity of Bristol
(author)
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Richmond, Rebecca CUniversity of Bristol
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Richardson, Tom GUniversity of Bristol
(author)
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Davey Smith, GeorgeUniversity of Bristol
(author)
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Relton, Caroline LUniversity of Bristol
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Huybrechts, IngeInternational Agency for Research on Cancer, World Health Organization
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University of BristolInternational Agency for Research on Cancer, World Health Organization
(creator_code:org_t)
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EPIC Network
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In:European Journal of Nutrition1436-6215
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Morales-Berstein ...
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Biessy, Carine
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Viallon, Vivian
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Goncalves-Soares ...
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Casagrande, Cori ...
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Hémon, Bertrand
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Kliemann, Nathal ...
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Cairat, Manon
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Blanco Lopez, Je ...
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Al Nahas, Aline
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Chang, Kiara
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Vamos, Eszter
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Rauber, Fernanda
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Bertazzi Levy, R ...
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Barbosa Cunha, D ...
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Jakszyn, Paula
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Ferrari, Pietro
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Vineis, Paolo
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Masala, Giovanna
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Catalano, Albert ...
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Sonestedt, Emily
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Borné, Yan
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Katzke, Verena
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Bajracharya, Ras ...
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Agnoli, Claudia
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Guevara, Marcela
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Heath, Alicia
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Radoï, Loredana
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Mancini, Frances ...
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Weiderpass, Elis ...
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Huerta, José Mar ...
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Sánchez, María-J ...
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Skeie, Guri
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Lukic, Marko
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Gunter, Marc
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Agudo, Antonio
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