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Effect of high-dose...
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Diness, Birgitte R.
(författare)
Effect of high-dose vitamin A supplementation on the immune response to Bacille Calmette-Guerin vaccines
- Artikel/kapitelEngelska2007
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LIBRIS-ID:oai:lup.lub.lu.se:ba14edba-4d94-410f-9e9e-173b433f974d
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https://lup.lub.lu.se/record/655529URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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Background: Vitamin A supplementation (VAS) at birth has been associated with decreased mortality in Asia. Bacille Calmette-Guerin (BCG) vaccine is given at birth in tuberculosis-endemic countries. Previous studies suggest that VAS may influence the immune response to vaccines. Objective: Our objective was to examine whether VAS influences the immune response to simultaneously administered BCG vaccine. Design: Within a randomized trial of 50 000 IU vitamin A or placebo Given with BCG vaccine at birth in Guinea-Bissau, 27 10 infants were examined for BCG scar formation and delayed-type hypersensitivity (DTH) to purified protein derivative of Mycobacterium tuberculosis (PPD) at 2 and 6 mo of age. The ex vivo cytokine response to PPD was measured in 607 infants. Results: At 2 mo of age, 39% (43% of the boys and 34% of the girls) responded to PPD. The prevalence ratio of a measurable PPD reaction for VAS compared with placebo recipients was 0.90 (95% CI: 0.80, 1.02) for all infants. 0.81 (95% CI: 0.69, 0.95) for boys, and 1.04 (95% CI: 0.86, 1.26) for girls. At 6 mo of age, 42% of the infants responded to PPD. No difference was observed between VAS and placebo recipients. The prevalence of BCG scar was not affected by VAS. The ex vivo interferon-gamma response to PPD was increased by VAS (means ratio: 1.40: 95% CI: 1.03, 1.91). Conclusions: VAS with BCG vaccination does not appear to interfere with the long-term immune response to BCG. However, VAS temporarily altered the DTH reaction to PPD in boys at 2 mo of age, suggesting sex differences in the immunologic response to VAS Given with BCG. This trial was registered at www.clinicaltrials.gov as #NCT00168597.
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Fisker, Ane B.
(författare)
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Roth, AdamLund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups(Swepub:lu)med-amr
(författare)
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Yazdanbakhsh, Maria
(författare)
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Sartono, Erliyani
(författare)
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Whittle, Hilton
(författare)
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Nante, Jose E.
(författare)
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Lisse, Ida M.
(författare)
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Ravn, Henrik
(författare)
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Rodrigues, Amabelia
(författare)
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Aaby, Peter
(författare)
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Benn, Christine S.
(författare)
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Klinisk mikrobiologi, MalmöForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:American Journal of Clinical Nutrition86:4, s. 1152-11591938-3207
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Diness, Birgitte ...
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Fisker, Ane B.
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Roth, Adam
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Yazdanbakhsh, Ma ...
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Sartono, Erliyan ...
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Whittle, Hilton
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Nante, Jose E.
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Lisse, Ida M.
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Ravn, Henrik
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Rodrigues, Amabe ...
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Aaby, Peter
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Benn, Christine ...
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