Search: id:"swepub:oai:lup.lub.lu.se:bafa582f-b8d0-4f59-995c-18c1f0988887" >
Type I Interferons ...
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Dahlgren, Madelene W.Lund University,Lunds universitet,Neuroinflammation,Forskargrupper vid Lunds universitet,Lund University Research Groups
(author)
Type I Interferons Promote Germinal Centers Through B Cell Intrinsic Signaling and Dendritic Cell Dependent Th1 and Tfh Cell Lineages
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-07-13
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Frontiers Media SA,2022
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:bafa582f-b8d0-4f59-995c-18c1f0988887
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https://lup.lub.lu.se/record/bafa582f-b8d0-4f59-995c-18c1f0988887URI
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https://doi.org/10.3389/fimmu.2022.932388DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Type I interferons (IFNs) are essential for antiviral immunity, appear to represent a key component of mRNA vaccine-adjuvanticity, and correlate with severity of systemic autoimmune disease. Relevant to all, type I IFNs can enhance germinal center (GC) B cell responses but underlying signaling pathways are incompletely understood. Here, we demonstrate that a succinct type I IFN response promotes GC formation and associated IgG subclass distribution primarily through signaling in cDCs and B cells. Type I IFN signaling in cDCs, distinct from cDC1, stimulates development of separable Tfh and Th1 cell subsets. However, Th cell-derived IFN-γ induces T-bet expression and IgG2c isotype switching in B cells prior to this bifurcation and has no evident effects once GCs and bona fide Tfh cells developed. This pathway acts in synergy with early B cell-intrinsic type I IFN signaling, which reinforces T-bet expression in B cells and leads to a selective amplification of the IgG2c+ GC B cell response. Despite the strong Th1 polarizing effect of type I IFNs, the Tfh cell subset develops into IL-4 producing cells that control the overall magnitude of the GCs and promote generation of IgG1+ GC B cells. Thus, type I IFNs act on B cells and cDCs to drive GC formation and to coordinate IgG subclass distribution through divergent Th1 and Tfh cell-dependent pathways.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Plumb, Adam W.Technical University of Denmark
(author)
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Niss, KristofferUniversity of Copenhagen
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Lahl, KatharinaLund University,Lunds universitet,Virusrekognition,Forskargrupper vid Lunds universitet,Virus Recognition,Lund University Research Groups,Technical University of Denmark(Swepub:lu)med-kl2
(author)
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Brunak, SørenUniversity of Copenhagen,Technical University of Denmark
(author)
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Johansson-Lindbom, BengtLund University,Lunds universitet,Adaptivt immunförsvar,Forskargrupper vid Lunds universitet,Adaptive Immunity,Lund University Research Groups,Technical University of Denmark(Swepub:lu)immt-bjo
(author)
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NeuroinflammationForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
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In:Frontiers in Immunology: Frontiers Media SA131664-3224
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