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Validity, reliabili...
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Merkel, Peter A
(författare)
Validity, reliability, and feasibility of durometer measurements of scleroderma skin disease in a multicenter treatment trial
- Artikel/kapitelEngelska2008
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:baff2709-1546-462f-8964-c0312e0d1074
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https://lup.lub.lu.se/record/1204372URI
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https://doi.org/10.1002/art.23564DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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Objective. To determine the validity, reliability, and feasibility of durometer measurements of skin hardness as an outcome measure in clinical trials of scleroderma. Methods. Skin hardness was measured during a multicenter treatment trial for scleroderma using handheld digital durometers with a continuous scale. Skin thickness was measured by modified Rodnan skin score (MRSS). Other outcome data collected included the Scleroderma Health Assessment Questionnaire. In a reliability exercise in advance of the trial, 9 investigators examined the same 5 scleroderma patients by MRSS and durometry. Results. Forty-three patients with early diffuse cutaneous systemic sclerosis were studied at 11 international centers (mean age 49 years [range 24-76], median disease duration 6.4 months [range 0.3-23], and median baseline MRSS 22 [range 11-38]). The reliability of durometer measurements was excellent, with high interobserver intraclass correlation coefficients (ICCs) (0.82-0.92), and each result was greater than the corresponding skin site ICCs for MRSS (0.54-0.85). Baseline durometer scores correlated well with MRSS (r = 0.69, P < 0.0001), patient self-assessments of skin disease (r = 0.69, P < 0.0001), and Health Assessment Questionnaire (HAQ) disability scores (r = 0.34, P = 0.03). Change in durometer scores correlated with change in MRSS (r = 0.70, P < 0.0001.), change in patient self-assessments of skin disease (r = 0.52, P = 0.003), and change in HAQ disability scores (r = 0.42, P = 0.017). The effect size was greater for durometry than for MRSS or patient self-assessment. Conclusion. Durometer measurements of skin hardness in patients with scleroderma are reliable, simple, accurate, demonstrate good sensitivity to change compared with traditional skin scoring, and reflect patients' self-assessments of their disease. Durometer measurements are valid, objective, and scalable, and should be considered for use as a complementary outcome measure to skin scoring in clinical trials of scleroderma.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Silliman, Nancy P
(författare)
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Denton, Christopher P
(författare)
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Furst, Daniel E
(författare)
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Khanna, Dinesh
(författare)
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Emery, Paul
(författare)
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Hsu, Vivien M
(författare)
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Streisand, James B
(författare)
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Polisson, Richard P
(författare)
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Åkesson, AnitaLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-aak
(författare)
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Coppock, John
(författare)
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van den Hoogen, Frank
(författare)
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Herrick, Ariane
(författare)
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Mayes, Maureen D
(författare)
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Veale, Douglas
(författare)
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Seibold, James R
(författare)
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Black, Carol M
(författare)
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Korn, Joseph H
(författare)
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Reumatologi och molekylär skelettbiologiSektion III
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Arthritis and Rheumatism: Wiley59:5, s. 699-7051529-01310004-3591
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Merkel, Peter A
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Silliman, Nancy ...
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Denton, Christop ...
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Furst, Daniel E
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Khanna, Dinesh
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Emery, Paul
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visa fler...
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Hsu, Vivien M
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Streisand, James ...
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Polisson, Richar ...
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Åkesson, Anita
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Coppock, John
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van den Hoogen, ...
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Herrick, Ariane
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Mayes, Maureen D
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Veale, Douglas
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Seibold, James R
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Black, Carol M
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Korn, Joseph H
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visa färre...
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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Lunds universitet