Natural killer cell activity and antibody-dependent cellular cytotoxicity in newborn infants

The ability of lymphocytes from the peripheral blood of preterm and term infants and adult women and men to mediate natural killing (NK) and K cell activity (antibody-dependent cellular cytotoxicity) was analysed in 4 hours 51Cr-release assays. K 562 cells were targets for NK activity. K cell activity was assayed on antibody-coated rat thymocytes. Lymphocytes from adult male donors were significantly more cytotoxic to K 562 cells than were lymphocytes from adult female donors. Lymphocytes from both preterm and term infants had significantly lower NK and K cell activity than lymphocytes from adult donors. During the first month of life no increase in NK activity or K cell activity occurred in 7 infants who were re-examined. It is concluded that neither NK nor K cell activities are fully developed during the first month of life.

Malmström, PLund University,Lunds universitet,Wallenberglaboratoriet, Lund,Medicinska fakulteten,The Wallenberg Laboratory,Faculty of Medicine,Skåne University Hospital(Swepub:lu)onk-pma (författare)
Lund UniversitySkåne University Hospital (creator_code:org_t)

Ingår i:Acta Paediatrica Scandinavica: Wiley71:3, s. 431-4360001-656X0803-52531651-2227

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