id:"swepub:oai:lup.lub.lu.se:bbc455f1-4d07-4fff-8ae6-a20ff9a63590"
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- Rosberg, Erik P.Skåne University Hospital,Lund University (author)
Family patterns of arterial stiffness across three generations in the Malmö Offspring Study
- Article/chapterEnglish2020
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- 2020
- 7 s.
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- LIBRIS-ID:oai:lup.lub.lu.se:bbc455f1-4d07-4fff-8ae6-a20ff9a63590
- https://lup.lub.lu.se/record/bbc455f1-4d07-4fff-8ae6-a20ff9a63590URI
- https://doi.org/10.1097/HJH.0000000000002293DOI
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- Language:English
- Summary in:English
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- Background:Central haemodynamics have in recent years emerged as a promising predictor of cardiovascular health and risk of cardiovascular disease (CVD). Central haemodynamics are affected early in the development of vascular aging and contributes to target organ damage. Carotid-femoral pulse wave velocity (c-f PWV), augmentation index (Aix) and central SBP (cSBP) are variables that reflect arterial stiffness and central haemodynamics.Aim:To study the association between patterns of central haemodynamics across three related generations focusing on c-f PWV.Methods:In all, 1131 participants from the Malmö Diet Cancer Study (MDCS) and Malmö Offspring Study (MOS) were included. c-f PWV was measured (Sphygmocor) in grandparents and in all offsprings. Correlation analyses of c-f PWV between offspring and c-f PWV in parents and grandparents were conducted. Parents and grandparents were stratified into quartiles by c-f PWV. Offspring c-f PWV means were compared with one-way ANOVA analyses. Multiple regression analyses were adjusted for age, sex, BMI, SBP and fasting glucose. Bonferroni corrections were used.Results:c-f PWV in offsprings was positively correlated with c-f PWV in parents (r = 0.26, P < 0.001) and in grandparents (r = 0.29, P < 0.001). Parents with high c-f PWV had offspring with significantly higher means of c-f PWV.Conclusion:A measure of aortic stiffness (c-f PWV) is positively correlated across three related generations in this population-based study.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
- arterial stiffness
- family
- generation
- heredity
- offspring
- pulse wave velocity
Added entries (persons, corporate bodies, meetings, titles ...)
- Nilsson, Peter M.Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-pni (author)
- Skåne University HospitalLund University (creator_code:org_t)
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- In:Journal of Hypertension38:3, s. 474-4800263-6352
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