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Relationships between abdominal aortic calcification, glomerular filtration rate, and cardiovascular risk factors in patients with non-dialysis dependent chronic kidney disease
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- Zhou, Yunan (författare)
- Lund University,Lunds universitet,Kliniska studier vid kronisk njursjukdom (CKD),Forskargrupper vid Lunds universitet,Clinical studies in CKD,Lund University Research Groups,Skåne University Hospital
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- Hellberg, Matthias (författare)
- Lund University,Lunds universitet,Kliniska studier vid kronisk njursjukdom (CKD),Forskargrupper vid Lunds universitet,Clinical studies in CKD,Lund University Research Groups,Skåne University Hospital
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- Kouidi, Evangelia (författare)
- Aristotle University of Thessaloniki
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- Deligiannis, Asterios (författare)
- Aristotle University of Thessaloniki
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- Höglund, Peter (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Kliniska studier vid kronisk njursjukdom (CKD),Forskargrupper vid Lunds universitet,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Clinical studies in CKD,Lund University Research Groups
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- Clyne, Naomi (författare)
- Lund University,Lunds universitet,Kliniska studier vid kronisk njursjukdom (CKD),Forskargrupper vid Lunds universitet,Clinical studies in CKD,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- 2018
- 2018
- Engelska 10 s.
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Ingår i: Clinical Nephrology. - 0301-0430. ; 90:6, s. 380-389
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.5...
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Abstract
Ämnesord
Stäng
- Background: Abdominal aortic calcification (AAC) is an established risk factor for cardiovascular events in patients with chronic kidney disease (CKD). We hypothesized that AAC is associated with a decline in glomerular filtration rate (GFR) as well as with some other cardiovascular risk factors. Materials and methods: This is a cross-sectional analysis of baseline data from a randomized controlled clinical trial (RENEXC). A total of 151 patients (aged 66 ± 14 years) with an average measured GFR (mGFR) of 22.5 ± 8.2 mL/min/1.73m2, not on renal replacement therapy, irrespective of number of comorbidities, were included. GFR was measured with iohexol clearance and estimated using cystatin C- and creatinine-based equations (eGFR). AAC was evaluated with lateral lumbar X-ray using the scoring system described by Kauppila. All patients underwent laboratory analyses, 24-hour ambulatory blood pressure monitoring, and standard echocardiography. Multiple linear regression analyses controlling for sex, age, cardiovascular comorbidities, and hypertension were performed. Results: The prevalence of AAC in this group of patients was 73%, and 47% had severe calcification (AAC score ≥ 7). More men (76%) had AAC than women (69%). AAC score was associated with mGFR (p = 0.03), eGFR (p = 0.006), plasma albumin (p = 0.006), plasma phosphate (p = 0.01), pulse pressure (p = 0.004), left ventricular mass (LVM) (p = 0.02), left atrial volume (LAV; p < 0.001), and left atrial volume index (LAVI; p = 0.001). Conclusion: AAC was highly prevalent in CKD. The degree of calcification in the abdominal aorta was strongly associated with a decline in GFR, a decrease in plasma albumin, an increase in plasma phosphate, an increase in pulse pressure, and cardiac structural changes, such as an increase in LVM, LAV, and LAVI.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Abdominal aortic calcification (AAC)
- Cardiovascular disease
- Chronic kidney disease (CKD)
- Echocardiographic index
- Glomerular filtration rate (GFR)
- Pulse pressure
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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