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Synthesis of alpha ...
Synthesis of alpha 1-microglobulin in cultured rat hepatocytes is stimulated by interleukin-6, leukemia inhibitory factor, dexamethasone and retinoic acid
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- Pierzchalski, P (author)
- Jagiellonian University
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Rokita, H (author)
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Koj, A (author)
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Fries, E (author)
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- Akerström, B (author)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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(creator_code:org_t)
- 1992
- 1992
- English.
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In: FEBS Letters. - 0014-5793. ; 298:2-3, s. 8-165
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The secretion of alpha 1-microglobulin by primary cultures of rat hepatocytes was found to increase upon the addition of interleukin-6 or leukemia inhibitory factor, two mediators of acute phase response. This stimulatory effect was further enhanced by dexamethasone. alpha 1-Microglobulin is synthesized as a precursor also containing bikunin, and the precursor protein is cleaved shortly before secretion. Our results therefore suggest that both alpha 1-microglobulin and bikunin are acute phase reactants in rat hepatocytes. Furthermore, we found that retinoic acid, previously shown to be involved in the regulation of cell differentiation and development, also stimulated alpha 1-microglobulin synthesis. Only free, uncomplexed alpha 1-microglobulin (28,000 Da) was detected in the hepatocyte media, suggesting that the complex between alpha 1-microglobulin and alpha 1-inhibitor 3, found in rat serum, is formed outside the hepatocyte.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Alpha-Globulins/biosynthesis
- Animals
- Cells, Cultured
- Chromatography, Gel
- Dexamethasone/pharmacology
- Growth Inhibitors/pharmacology
- Immunoblotting
- Interleukin-6/pharmacology
- Leukemia Inhibitory Factor
- Liver/drug effects
- Lymphokines/pharmacology
- Rats
- Rats, Inbred Strains
- Tretinoin/pharmacology
Publication and Content Type
- art (subject category)
- ref (subject category)
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