Impact of Di-2-Ethylhexyl Phthalate Metabolites on Male Reproductive Function : a Systematic Review of Human Evidence

PURPOSE OF REVIEW: The purpose of this review is to systematically review the literature linking di-2-ethylhexyl phthalate (DEHP) exposure with effects on reproductive health in adult males. RECENT FINDINGS: Thirty-three papers were included of which 28 were cross-sectional. Twenty-one papers investigated semen samples, 18 investigated reproductive hormones, and three studies investigated time to pregnancy. Studies revealed some but inconsistent indications that higher urinary DEHP metabolite levels are associated with an increase in the proportion of spermatozoa with damaged DNA and to a decrease in sperm concentration and motility. A negative association between DEHP metabolites and testosterone levels was more consistent. DEHP metabolites do not seem to be associated with a delay in time to pregnancy, but data are sparse. The studies on DEHP exposure and reproductive biomarkers in men converge to support the hypothesis that DEHP exposure is related to impaired male reproductive function. Longitudinal studies are needed to establish if the observed associations are causal.

Lenters, VirissaNorwegian Institute of Public Health (author)
Giwercman, AleksanderLund University,Lunds universitet,Molekylärgenetisk reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Molecular genetic reproductive medicine, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)kir-agi (author)
Jönsson, Bo A.G.Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)ymed-bjo (author)
Toft, GunnarAarhus University (author)
Hougaard, Karin S.The National Research Centre for the Working Environment,University of Copenhagen (author)
Bonde, Jens Peter E.Frederiksberg Hospital (author)
Specht, Ina OlmerFrederiksberg Hospital (author)
Frederiksberg HospitalNorwegian Institute of Public Health (creator_code:org_t)

In:Current Environmental Health Reports: Springer Science and Business Media LLC5:1, s. 20-332196-5412

By the author/editor: Høyer, Birgit Bj ...; Lenters, Virissa; Giwercman, Aleks ...; Jönsson, Bo A.G.; Toft, Gunnar; Hougaard, Karin ...; show more...; Bonde, Jens Pete ...; Specht, Ina Olme ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Occupational Hea ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

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