Prognostic significance of body temperature in the emergency department vs the ICU in Patients with severe sepsis or septic shock : A nationwide cohort study

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Inghammar, MalinLund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital (författare)

Prognostic significance of body temperature in the emergency department vs the ICU in Patients with severe sepsis or septic shock : A nationwide cohort study

Artikel/kapitelEngelska2020

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2020-12-29
Public Library of Science (PLoS),2020

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LIBRIS-ID:oai:lup.lub.lu.se:bc936c14-6b10-468d-a886-1d2dcb8cb9e9
https://lup.lub.lu.se/record/bc936c14-6b10-468d-a886-1d2dcb8cb9e9URI
https://doi.org/10.1371/journal.pone.0243990DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:145598444URI

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Språk:engelska
Sammanfattning på:engelska

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Background Increased body temperature in the Emergency Department (BT-ED) and the ICU (BT-ICU) is associated with lower mortality in patients with sepsis. Here, we compared how well BTED and BT-ICU predict mortality; investigated mortality in various combinations of BT-ED and BT-ICU, and; compared degree of fever in the ED and ICU and associated quality of care. Methods 2385 adults who were admitted to an ICU within 24 hours of ED arrival with severe sepsis or septic shock were included. Results Thirty-day mortality was 23.6%. Median BT-ED and BT-ICU was 38.1 and 37.6°C. Crude mortality decreased more than 5% points per°C increase for both BT-ED and BT-ICU. Adjusted OR for mortality was 0.82/°C increase for BT-ED (0.76-0.88, p < 0.001), and 0.89 for BT-ICU (0.83-0.95, p<0.001). Patients who were at/below median temperature in both the ED and in the ICU had the highest mortality, 32%, and those with over median in the ED and at/below in the ICU had the lowest, 16%, (p<0.001). Women had 0.2°C lower median BT-ED (p = 0.03) and 0.3°C lower BT-ICU (p<0.0001) than men. Older patients had lower BT in the ICU, but not in the ED. Fever was associated with a higher rate of sepsis bundle achievement in the ED, but lower nurse workload in the ICU. Conclusions BT-ED was more useful to prognosticate mortality than BT-ICU. Despite better prognosis in patients with elevated BT, fever was associated with higher quality of care in the ED. Future studies should assess how BT-ED can be used to improve triage of infected patients, assigning higher priority to patients with low-grade/no fever and vice versa. Patients with at/ below median BT in both ED and ICU have the highest mortality and should receive special attention. Different BT according to sex and age also needs further study.

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Sunden-Cullberg, JonasKarolinska Institutet,Karolinska Institute,Karolinska University Hospital (författare)
InfektionsmedicinSektion III (creator_code:org_t)

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Ingår i:PLoS ONE: Public Library of Science (PLoS)15:12 December1932-6203

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Av författaren/redakt...: Inghammar, Malin; Sunden-Cullberg, ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Anestesi och int ...

Artiklar i publikationen: PLoS ONE

Av lärosätet: Lunds universitet; Karolinska Institutet

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