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Search: onr:"swepub:oai:lup.lub.lu.se:bdae2527-bc0d-4251-9ed4-bf8e3048f839" > Molecular and clini...

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  • Darenberg, JessicaKarolinska Institutet (author)

Molecular and clinical characteristics of invasive group A streptococcal infection in Sweden

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • Oxford University Press (OUP),2007

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:bdae2527-bc0d-4251-9ed4-bf8e3048f839
  • https://lup.lub.lu.se/record/584854URI
  • https://doi.org/10.1086/519936DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-21726URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:115639138URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background. The incidence and severity of invasive group A streptococcal infection demonstrate great variability over time, which at least, in part, seems to be related to group A streptococcal type distribution among the human population. Methods. An enhanced surveillance study of invasive group A streptococcal infection (746 isolates) was performed in Sweden from April 2002 through December 2004. Noninvasive isolates from either the throat or skin (773 isolates) were collected in parallel for comparison. Clinical and epidemiological data were obtained from 88% of patients with invasive disease and were related to isolate characteristics, including T type, emm sequence type, and the presence of 9 superantigen genes, as well as pulsed-field gel electrophoresis pattern comparisons of selected isolates. Results. The annual incidence was 3.0 cases per 100,000 population. Among the patients with invasive disease, 11% developed streptococcal toxic shock syndrome, and 9.5% developed necrotizing fasciitis. The overall case-fatality rate was 14.5%, and 39% of the patients with streptococcal toxic shock syndrome died (P < .001). The T3/13/B3264 cluster accounted for 33% of invasive and 25% of noninvasive isolates. Among this most prevalent type cluster, emm types 89 and 81 dominated. Combined results from pulsed-field gel electrophoresis, emm typing, and superantigen gene profiling identified subgroups within specific emm types that are significantly more prone to cause invasive disease than were other isolates of the same type. Conclusions. This study revealed a changing epidemiology of invasive group A streptococcal infection in Sweden, with emergence of new emm types that were previously not described. The results also suggest that some clones may be particularly prone to cause invasive disease.

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  • Luca, BogdanLund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)med-bl- (author)
  • Jasir, AftabLund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)mmb-aja (author)
  • Sandgren, Andreas (author)
  • Pettersson, Helena (author)
  • Scahlén, Claes (author)
  • Norgren, MariUmeå universitet,Institutionen för klinisk mikrobiologi,Biomedicinsk laboratorievetenskap (author)
  • Romanus, Victoria (author)
  • Norrby-Teglund, AnnaKarolinska Institutet (author)
  • Henriques Normark, BirgittaKarolinska Institutet (author)
  • Karolinska InstitutetAvdelningen för medicinsk mikrobiologi (creator_code:org_t)

Related titles

  • In:Clinical Infectious Diseases: Oxford University Press (OUP)45:4, s. 8-4501537-65911058-4838

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