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Physiological prope...
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Johansson, Ann-CathrineLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
(författare)
Physiological properties of the peritoneum in an adult peritoneal dialysis population over a three-year period
- Artikel/kapitelEngelska2006
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LIBRIS-ID:oai:lup.lub.lu.se:bdbc8b80-af57-4ba2-9af6-ff0be9710690
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https://lup.lub.lu.se/record/686295URI
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https://gup.ub.gu.se/publication/49246URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Objectives: To describe the physiological properties of the peritoneal membrane in adult patients treated with peritoneal dialysis (PD) and to analyze the effects of patient characteristics and time. Design: Observational study. Setting: Department of Nephrology at the Sahlgrenska University Hospital. Method: Peritoneal function was analyzed by the Personal Dialysis Capacity (PDC) test, based on the three-pore theory of capillary transport. The functional PDC variables are absorption, large-pore flow, and the area parameter (A(0)/Delta x), which determines the diffusion of small solutes. The ultrafiltration (UF) coefficient is determined mainly by A(0)/Delta x. Patients: All patients (n = 280) who had at least one PDC test done between September 1990 and August 1999. Results: In 249 patients examined soon after start of PD, area was 19000 (SD 7100) cm(2)/cm/1.73 m(2), large-pore flow 0.112 (SD 0.052) mL/min/1.73 m(2), and the UF coefficient 0.071 (SD 0.032) mL/minute/mmHg/1.73 m(2). Absorption was 1.54 (SD +2.64, -0.97) mL/min/1.73 m(2). Large-pore flow was greater in patients with severe comorbidity than in patients with fewer comorbid conditions. Elderly patients had a lower UF coefficient than did younger patients (p < 0.05). Repeated PDC tests were performed in 208 patients during a mean observation time of 18.4 months. There was a slight increase in the slope of the area-versus-time curve of 54 cm(2)/cm/1.73 m(2) per month (approximately 10% after 3 years, p < 0.01); all other parameters remained constant. Conclusion: Patient characteristics have an impact on peritoneal performance already at the start of dialysis. Peritoneal function can remain essentially stable during medium long-term PD.
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Haraldsson, Börje,1957Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xharbo
(författare)
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Institutionen för kliniska vetenskaper, MalmöMedicinska fakulteten
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Peritoneal Dialysis International26:4, s. 482-91718-4304
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Ingår i:Perit Dial Int26:4, s. 482-90896-8608
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