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Sökning: id:"swepub:oai:lup.lub.lu.se:be01924e-db54-4a9b-9602-f6dc9564519d" > Perivascular PDGFR-...

  • Frödin, MagnusKarolinska Institutet,Karolinska Institute (författare)

Perivascular PDGFR-β is an independent marker for prognosis in renal cell carcinoma

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • 2016-12-08
  • Springer Science and Business Media LLC,2017
  • 7 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:be01924e-db54-4a9b-9602-f6dc9564519d
  • https://lup.lub.lu.se/record/be01924e-db54-4a9b-9602-f6dc9564519dURI
  • https://doi.org/10.1038/bjc.2016.407DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:135240230URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Background:Renal cell carcinoma (RCC) is a highly vascularised tumour, where anti-Angiogenic treatment with multi-Tyrosine-kinase-inhibitor, is used for first-line treatment of metastatic disease. Variations in vascular characteristics are likely to contribute to variations in intrinsic aggressiveness of the disease. Emerging studies are identifying perivascular status, including perivascular PDGFR-β, as a determinant of prognosis in other tumour types.Methods:This work explored the impact on prognosis of vascular characteristics in RCC through analyses of a population-based collection of tumours from surgery-Alone-Treated patients. The quantitative data from a panel of vascular metrics were obtained through computerised image analysis of sections double-stained for expression of the endothelial cell marker CD34 together with perivascular markers α-SMA or PDGFR-β.Results:Perivascular expression of PDGFR-β and α-SMA were positively correlated to each other, and negatively correlated to vessel density. High expression of PDGFR-β and α-SMA as well as low vessel density was significantly associated with short survival in uni-and multivariate analyses. Subgroup analyses demonstrated that the prognostic impact of the perivascular markers was particularly prominent in the T4-subgroup. A novel metric, related to PDGFR-β perivascular heterogeneity, was also associated with prognosis in uni-And multi-variate analyses. This novel metric also acted as a prognosis marker in ovarian cancer.Conclusions:The study demonstrates previously unrecognised associations between RCC survival and the absolute levels, and variability, of perivascular PDGFR-β. This marker should be further explored in other RCC cohorts. Findings also suggest mechanistic analyses and studies on the relationship between perivascular status and efficacy of multi-Tyrosine-kinase-inhibitors.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Mezheyeuski, ArturKarolinska Institutet,Karolinska Institute (författare)
  • Corvigno, SaraKarolinska Institutet,Karolinska Institute (författare)
  • Harmenberg, UlrikaKarolinska Institutet,Karolinska Institute,Karolinska University Hospital (författare)
  • Sandström, Per-ErikKarolinska Institute (författare)
  • Egevad, LarsKarolinska Institutet,Karolinska Institute,Karolinska University Hospital (författare)
  • Johansson, MartinLund University,Lunds universitet,Klinisk patologi, Malmö,Forskargrupper vid Lunds universitet,Clinical pathology, Malmö,Lund University Research Groups(Swepub:lu)med-mim (författare)
  • Östman, ArneKarolinska Institutet,Karolinska Institute (författare)
  • Karolinska InstitutetKarolinska Institute (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:British Journal of Cancer: Springer Science and Business Media LLC116:2, s. 195-2010007-09201532-1827

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