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Perivascular PDGFR-...
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Frödin, MagnusKarolinska Institutet,Karolinska Institute
(författare)
Perivascular PDGFR-β is an independent marker for prognosis in renal cell carcinoma
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
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2016-12-08
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Springer Science and Business Media LLC,2017
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7 s.
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:be01924e-db54-4a9b-9602-f6dc9564519d
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https://lup.lub.lu.se/record/be01924e-db54-4a9b-9602-f6dc9564519dURI
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https://doi.org/10.1038/bjc.2016.407DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:135240230URI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Background:Renal cell carcinoma (RCC) is a highly vascularised tumour, where anti-Angiogenic treatment with multi-Tyrosine-kinase-inhibitor, is used for first-line treatment of metastatic disease. Variations in vascular characteristics are likely to contribute to variations in intrinsic aggressiveness of the disease. Emerging studies are identifying perivascular status, including perivascular PDGFR-β, as a determinant of prognosis in other tumour types.Methods:This work explored the impact on prognosis of vascular characteristics in RCC through analyses of a population-based collection of tumours from surgery-Alone-Treated patients. The quantitative data from a panel of vascular metrics were obtained through computerised image analysis of sections double-stained for expression of the endothelial cell marker CD34 together with perivascular markers α-SMA or PDGFR-β.Results:Perivascular expression of PDGFR-β and α-SMA were positively correlated to each other, and negatively correlated to vessel density. High expression of PDGFR-β and α-SMA as well as low vessel density was significantly associated with short survival in uni-and multivariate analyses. Subgroup analyses demonstrated that the prognostic impact of the perivascular markers was particularly prominent in the T4-subgroup. A novel metric, related to PDGFR-β perivascular heterogeneity, was also associated with prognosis in uni-And multi-variate analyses. This novel metric also acted as a prognosis marker in ovarian cancer.Conclusions:The study demonstrates previously unrecognised associations between RCC survival and the absolute levels, and variability, of perivascular PDGFR-β. This marker should be further explored in other RCC cohorts. Findings also suggest mechanistic analyses and studies on the relationship between perivascular status and efficacy of multi-Tyrosine-kinase-inhibitors.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Mezheyeuski, ArturKarolinska Institutet,Karolinska Institute
(författare)
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Corvigno, SaraKarolinska Institutet,Karolinska Institute
(författare)
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Harmenberg, UlrikaKarolinska Institutet,Karolinska Institute,Karolinska University Hospital
(författare)
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Sandström, Per-ErikKarolinska Institute
(författare)
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Egevad, LarsKarolinska Institutet,Karolinska Institute,Karolinska University Hospital
(författare)
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Johansson, MartinLund University,Lunds universitet,Klinisk patologi, Malmö,Forskargrupper vid Lunds universitet,Clinical pathology, Malmö,Lund University Research Groups(Swepub:lu)med-mim
(författare)
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Östman, ArneKarolinska Institutet,Karolinska Institute
(författare)
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Karolinska InstitutetKarolinska Institute
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:British Journal of Cancer: Springer Science and Business Media LLC116:2, s. 195-2010007-09201532-1827
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