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Maternal vitamin D ...
Maternal vitamin D levels and male reproductive health : a population-based follow-up study
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- Gaml-Sørensen, Anne (author)
- University of California, Los Angeles,Aarhus University
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- Brix, Nis (author)
- Aarhus University,Aarhus University Hospital
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- Hærvig, Katia Keglberg (author)
- Frederiksberg Hospital
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- Lindh, Christian (author)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups
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- Tøttenborg, Sandra Søgaard (author)
- University of Copenhagen,Frederiksberg Hospital
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- Hougaard, Karin Sørig (author)
- The National Research Centre for the Working Environment,University of Copenhagen
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- Høyer, Birgit Bjerre (author)
- Aarhus University,Vejle Hospital
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- Ernst, Andreas (author)
- Aarhus University,Aarhus University Hospital
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- Arendt, Linn Håkonsen (author)
- Aarhus University Hospital,Aarhus University
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- Clemmensen, Pernille Jul (author)
- Aarhus University
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- Bonde, Jens Peter Ellekilde (author)
- University of Copenhagen,Frederiksberg Hospital
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- Henriksen, Tine Brink (author)
- Aarhus University,Aarhus University Hospital
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- Toft, Gunnar (author)
- Aarhus University Hospital
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- Arah, Onyebuchi A. (author)
- Aarhus University,University of California, Los Angeles
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- Ramlau-Hansen, Cecilia Høst (author)
- University of California, Los Angeles,Aarhus University
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(creator_code:org_t)
- 2023-03-23
- 2023
- English 16 s.
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In: European Journal of Epidemiology. - : Springer Science and Business Media LLC. - 0393-2990 .- 1573-7284. ; 38:5, s. 469-484
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Maternal vitamin D levels during pregnancy may be important for reproductive health in male offspring by regulating cell proliferation and differentiation during development. We conducted a follow-up study of 827 young men from the Fetal Programming of Semen Quality (FEPOS) cohort, nested in the Danish National Birth Cohort to investigate if maternal vitamin D levels were associated with measures of reproductive health in adult sons. These included semen characteristics, testes volume, and reproductive hormone levels and were analysed according to maternal vitamin D (25(OH)D3) levels during pregnancy. In addition, an instrumental variable analysis using seasonality in sun exposure as an instrument for maternal vitamin D levels was conducted. We found that sons of mothers with vitamin D levels < 25 nmol/L had 11% (95% CI − 19 to − 2) lower testes volume and a 1.4 (95% CI 1.0 to 1.9) times higher risk of having low testes volume (< 15 mL), in addition to 20% (95% CI − 40 to 9) lower total sperm count and a 1.6 (95% CI 0.9 to 2.9) times higher risk of having a low total sperm count (< 39 million) compared with sons of mothers with vitamin D levels > 75 nmol/L. Continuous models, spline plots and an instrumental variable analysis supported these findings. Low maternal vitamin D levels were associated with lower testes volume and lower total sperm count with indications of dose-dependency. Maternal vitamin D level above 75 nmol/L during pregnancy may be beneficial for testes function in adult sons.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- 25-hydroxyvitamin D
- Instrumental variable analysis
- Prenatal exposure
- Reproductive hormones
- Semen quality
- Testes volume
Publication and Content Type
- art (subject category)
- ref (subject category)
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Gaml-Sørensen, A ...
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Brix, Nis
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Hærvig, Katia Ke ...
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Lindh, Christian
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Tøttenborg, Sand ...
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Hougaard, Karin ...
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Høyer, Birgit Bj ...
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Ernst, Andreas
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Arendt, Linn Håk ...
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Clemmensen, Pern ...
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Bonde, Jens Pete ...
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Henriksen, Tine ...
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Toft, Gunnar
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Arah, Onyebuchi ...
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Ramlau-Hansen, C ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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European Journal ...
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Lund University