Cerebrospinal fluid soluble TREM2 in aging and Alzheimer's disease

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Henjum, KristiOslo university hospital (author)

Cerebrospinal fluid soluble TREM2 in aging and Alzheimer's disease

Article/chapterEnglish2016

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2016-04-27
Springer Science and Business Media LLC,2016

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LIBRIS-ID:oai:lup.lub.lu.se:bf6411c3-1b75-4d4e-a0b6-718e0787b3a4
https://lup.lub.lu.se/record/bf6411c3-1b75-4d4e-a0b6-718e0787b3a4URI
https://doi.org/10.1186/s13195-016-0182-1DOI

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Language:English
Summary in:English

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Background: Alzheimer's disease (AD) neuropathology is associated with neuroinflammation, but there are few useful biomarkers. Mutant variants of triggering receptor expressed on myeloid cells 2 (TREM2) have recently been linked to late-onset AD and other neurodegenerative disorders. TREM2, a microglial receptor, is involved in innate immunity. A cleaved fragment, soluble TREM2 (sTREM2), is present in the cerebrospinal fluid (CSF). Methods: We developed and used a novel enzyme-linked immunosorbent assay to investigate the potential value of CSF sTREM2 as an AD biomarker in two independent cohorts: an AD/mild cognitive impairment (MCI)/control cohort (n = 100) and an AD/control cohort (n = 50). Results: We found no significant difference in sTREM2 levels between groups of controls and patients with AD or MCI. However, among all controls there was a positive correlation between sTREM2 and age (Spearman rho = 0.50; p <0.001; n = 75). In the AD/MCI/control cohort, CSF sTREM2 correlated positively with total Tau (T-tau) (Spearman rho 0.57; p <0.001; n = 50), phosphorylated Tau (P-tau) (Spearman rho 0.63; p <0.001; n = 50) and amyloid-β1-42 (Aβ42) (Spearman rho 0.35; p = 0.01; n = 50) in control subjects. Among controls with a CSF Aβ42 above a cut-off value (700 pg/ml) in this cohort, the positive correlation between sTREM2 and Aβ42 was stronger (Spearman rho = 0.44; p = 0.002; n = 46). Conclusions: sTREM2 in CSF correlates with aging in controls, and with the neurodegenerative markers CSF T-tau/P-tau among controls who are negative for AD CSF core biomarkers Aβ42, T-tau or P-tau.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
Aging
Alzheimer's disease
Amyloid beta
Microgliosis
Mild cognitive impairment
Neuroinflammation
Soluble TREM2
Tau

Added entries (persons, corporate bodies, meetings, titles ...)

Almdahl, Ina S.Akershus University Hospital (author)
Årskog, VibekeOslo university hospital (author)
Minthon, LennartLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)psyk-lmi (author)
Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)mphy-ohn (author)
Fladby, TormodAkershus University Hospital (author)
Nilsson, Lars N GOslo university hospital (author)
Oslo university hospitalAkershus University Hospital (creator_code:org_t)

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In:Alzheimer's Research & Therapy: Springer Science and Business Media LLC8:11758-9193

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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By the university: Lund University

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