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  • Munk, Anne SofieUniversity of Copenhagen,University of Rochester,Univ Rochester, Ctr Translat Neuromed, Rochester, NY 14642 USA;Univ Copenhagen, Ctr Basic & Translat Neurosci, DK-2200 Copenhagen, Denmark (author)

PDGF-B Is Required for Development of the Glymphatic System

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • Elsevier BV,2019

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  • LIBRIS-ID:oai:lup.lub.lu.se:bff239d6-b21e-4fe9-8fb3-e626a1bb694a
  • https://lup.lub.lu.se/record/bff239d6-b21e-4fe9-8fb3-e626a1bb694aURI
  • https://doi.org/10.1016/j.celrep.2019.02.050DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:140489514URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-380455URI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways. Herein we have mapped the development of the glymphatic system in mice. Perivascular CSF transport first emerges in hippocampus in newborn mice, and a mature glymphatic system is established in the cortex at 2 weeks of age. Formation of astrocytic endfeet and polarized expression of aquaporin 4 (AQP4) consistently coincided with the appearance of perivascular CSF transport. Deficiency of platelet-derived growth factor B (PDGF-B) function in the PDGF retention motif knockout mouse line Pdgfb ret/ret suppressed the development of the glymphatic system, whose functions remained suppressed in adulthood compared with wild-type mice. These experiments map the natural development of the glymphatic system in mice and define a critical role of PDGF-B in the development of perivascular CSF transport.

Subject headings and genre

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  • Wang, WeiUniversity of Rochester,Univ Rochester, Ctr Translat Neuromed, Rochester, NY 14642 USA (author)
  • Bèchet, Nicholas BurdonLund University,Lunds universitet,Glia-Immune Interactions,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Lund Univ, Dept Expt Med Sci, S-22184 Lund, Sweden;Lund Univ, Wallenberg Ctr Mol Med, S-22184 Lund, Sweden(Swepub:lu)ni6106be (author)
  • Eltanahy, Ahmed M.Mansoura University Hospital,Lund Univ, Dept Expt Med Sci, S-22184 Lund, Sweden;Lund Univ, Wallenberg Ctr Mol Med, S-22184 Lund, Sweden;Mansoura Univ, Mansoura Univ Hosp, Fac Med, Mansoura 35516, Egypt (author)
  • Cheng, Anne XiaoanUniversity of Rochester,Univ Rochester, Ctr Translat Neuromed, Rochester, NY 14642 USA (author)
  • Sigurdsson, BjörnUniversity of Copenhagen,Univ Copenhagen, Ctr Basic & Translat Neurosci, DK-2200 Copenhagen, Denmark (author)
  • Benraiss, AbdellatifUniversity of Rochester,Univ Rochester, Ctr Translat Neuromed, Rochester, NY 14642 USA (author)
  • Mäe, Maarja AndaloussiUppsala universitet,Uppsala University,Vaskulärbiologi(Swepub:uu)maaan970 (author)
  • Kress, Benjamin TravisUniversity of Rochester,University of Copenhagen,Univ Rochester, Ctr Translat Neuromed, Rochester, NY 14642 USA;Univ Copenhagen, Ctr Basic & Translat Neurosci, DK-2200 Copenhagen, Denmark (author)
  • Kelley, Douglas H.University of Rochester,Univ Rochester, Dept Mech Engn, Rochester, NY 14627 USA (author)
  • Betsholtz, ChristerUppsala universitet,Karolinska Institutet,Uppsala University,Karolinska Institute,Vaskulärbiologi,Karolinska Inst, ICMC, S-14157 Huddinge, Sweden(Swepub:uu)chbet517 (author)
  • Møllgård, KjeldUniversity of Copenhagen,Univ Copenhagen, Dept Cellular & Mol Med, DK-2200 Copenhagen, Denmark (author)
  • Meissner, AnjaLund University,Lunds universitet,Vaskulär biologi,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Vascular Biology,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Lund Univ, Dept Expt Med Sci, S-22184 Lund, Sweden;Lund Univ, Wallenberg Ctr Mol Med, S-22184 Lund, Sweden(Swepub:lu)an0178me (author)
  • Nedergaard, MaikenUniversity of Copenhagen,University of Rochester,Univ Rochester, Ctr Translat Neuromed, Rochester, NY 14642 USA;Univ Copenhagen, Ctr Basic & Translat Neurosci, DK-2200 Copenhagen, Denmark (author)
  • Lundgaard, IbenLund University,Lunds universitet,Glia-Immune Interactions,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,University of Rochester,Univ Rochester, Ctr Translat Neuromed, Rochester, NY 14642 USA;Lund Univ, Dept Expt Med Sci, S-22184 Lund, Sweden;Lund Univ, Wallenberg Ctr Mol Med, S-22184 Lund, Sweden(Swepub:lu)ib4521lu (author)
  • University of CopenhagenUniversity of Rochester (creator_code:org_t)

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  • In:Cell Reports: Elsevier BV, s. 3-29692211-1247

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