Search: WFRF:(Eltanahy Ahmed M.) >
PDGF-B Is Required ...
PDGF-B Is Required for Development of the Glymphatic System
-
- Munk, Anne Sofie (author)
- University of Rochester,University of Copenhagen,Univ Rochester, Ctr Translat Neuromed, Rochester, NY 14642 USA;Univ Copenhagen, Ctr Basic & Translat Neurosci, DK-2200 Copenhagen, Denmark
-
- Wang, Wei (author)
- University of Rochester,Univ Rochester, Ctr Translat Neuromed, Rochester, NY 14642 USA
-
- Bèchet, Nicholas Burdon (author)
- Lund University,Lunds universitet,Glia-Immune Interactions,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Lund Univ, Dept Expt Med Sci, S-22184 Lund, Sweden;Lund Univ, Wallenberg Ctr Mol Med, S-22184 Lund, Sweden
-
show more...
-
- Eltanahy, Ahmed M. (author)
- Mansoura University Hospital,Mansoura University,Lund Univ, Dept Expt Med Sci, S-22184 Lund, Sweden;Lund Univ, Wallenberg Ctr Mol Med, S-22184 Lund, Sweden;Mansoura Univ, Mansoura Univ Hosp, Fac Med, Mansoura 35516, Egypt
-
- Cheng, Anne Xiaoan (author)
- University of Rochester,Univ Rochester, Ctr Translat Neuromed, Rochester, NY 14642 USA
-
- Sigurdsson, Björn (author)
- University of Copenhagen,Univ Copenhagen, Ctr Basic & Translat Neurosci, DK-2200 Copenhagen, Denmark
-
- Benraiss, Abdellatif (author)
- University of Rochester,Univ Rochester, Ctr Translat Neuromed, Rochester, NY 14642 USA
-
- Mäe, Maarja Andaloussi (author)
- Uppsala universitet,Uppsala University,Vaskulärbiologi
-
- Kress, Benjamin Travis (author)
- University of Rochester,University of Copenhagen,Univ Rochester, Ctr Translat Neuromed, Rochester, NY 14642 USA;Univ Copenhagen, Ctr Basic & Translat Neurosci, DK-2200 Copenhagen, Denmark
-
- Kelley, Douglas H. (author)
- University of Rochester,Univ Rochester, Dept Mech Engn, Rochester, NY 14627 USA
-
- Betsholtz, Christer (author)
- Uppsala universitet,Karolinska Institutet,Uppsala University,Karolinska Institute,Vaskulärbiologi,Karolinska Inst, ICMC, S-14157 Huddinge, Sweden
-
- Møllgård, Kjeld (author)
- University of Copenhagen,Univ Copenhagen, Dept Cellular & Mol Med, DK-2200 Copenhagen, Denmark
-
- Meissner, Anja (author)
- Lund University,Lunds universitet,Vaskulär biologi,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Vascular Biology,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Lund Univ, Dept Expt Med Sci, S-22184 Lund, Sweden;Lund Univ, Wallenberg Ctr Mol Med, S-22184 Lund, Sweden
-
- Nedergaard, Maiken (author)
- University of Copenhagen,University of Rochester,Univ Rochester, Ctr Translat Neuromed, Rochester, NY 14642 USA;Univ Copenhagen, Ctr Basic & Translat Neurosci, DK-2200 Copenhagen, Denmark
-
- Lundgaard, Iben (author)
- Lund University,Lunds universitet,Glia-Immune Interactions,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,University of Rochester,Univ Rochester, Ctr Translat Neuromed, Rochester, NY 14642 USA;Lund Univ, Dept Expt Med Sci, S-22184 Lund, Sweden;Lund Univ, Wallenberg Ctr Mol Med, S-22184 Lund, Sweden
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
-
In: Cell Reports. - : Elsevier BV. - 2211-1247. ; , s. 3-2969
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
http://www.cell.com/...
-
https://doi.org/10.1...
-
https://uu.diva-port... (primary) (Raw object)
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
http://kipublication...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways. Herein we have mapped the development of the glymphatic system in mice. Perivascular CSF transport first emerges in hippocampus in newborn mice, and a mature glymphatic system is established in the cortex at 2 weeks of age. Formation of astrocytic endfeet and polarized expression of aquaporin 4 (AQP4) consistently coincided with the appearance of perivascular CSF transport. Deficiency of platelet-derived growth factor B (PDGF-B) function in the PDGF retention motif knockout mouse line Pdgfb ret/ret suppressed the development of the glymphatic system, whose functions remained suppressed in adulthood compared with wild-type mice. These experiments map the natural development of the glymphatic system in mice and define a critical role of PDGF-B in the development of perivascular CSF transport.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- aquaporin 4
- astrocytes
- cerebrospinal fluid
- glymphatic system
- platelet-derived growth factor B
- postnatal development
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Munk, Anne Sofie
-
Wang, Wei
-
Bèchet, Nicholas ...
-
Eltanahy, Ahmed ...
-
Cheng, Anne Xiao ...
-
Sigurdsson, Björ ...
-
show more...
-
Benraiss, Abdell ...
-
Mäe, Maarja Anda ...
-
Kress, Benjamin ...
-
Kelley, Douglas ...
-
Betsholtz, Chris ...
-
Møllgård, Kjeld
-
Meissner, Anja
-
Nedergaard, Maik ...
-
Lundgaard, Iben
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
- Articles in the publication
-
Cell Reports
- By the university
-
Lund University
-
Karolinska Institutet
-
Uppsala University