Exploration of Physiological and Pathophysiological Implications of miRNA-143 and miRNA-145 in Cerebral Arteries

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Christensen, Simon ToppCopenhagen University Hospital (författare)

Exploration of Physiological and Pathophysiological Implications of miRNA-143 and miRNA-145 in Cerebral Arteries

Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

2019
11 s.

Nummerbeteckningar

LIBRIS-ID:oai:lup.lub.lu.se:c043f78b-99b4-4501-84ca-088a29572e0e
https://lup.lub.lu.se/record/c043f78b-99b4-4501-84ca-088a29572e0eURI
https://doi.org/10.1097/FJC.0000000000000735DOI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:ref swepub-contenttype

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Subarachnoid hemorrhage (SAH) is a type of hemorrhagic stroke with a high short-term mortality rate which leads to cognitive impairments that reduce the quality of life of the majority of patients. The miRNA-143/145 cluster is highly expressed in vascular smooth muscle cells (VSMC) and has been shown to be necessary for differentiation and function, as well as an important determinant for phenotypic modulation/switching of VSMCs in response to vascular injury. We aimed to determine whether miRNA-143 and miRNA-145 are important regulators of phenotypical changes of VSMCs in relation to SAH, as well as establishing their physiological role in the cerebral vasculature. We applied quantitative PCR to study ischemia-induced alterations in the expression of miRNA-143 and miRNA-145, for rat cerebral vasculature, in an ex vivo organ culture model and an in vivo SAH model. To determine the physiological importance, we did myograph studies on basilar and femoral arteries from miRNA-143/145 knockout mice. miRNA-143 and miRNA-145 are not upregulated in the vasculature following our SAH model, despite the upregulation of miR-145 in the organ culture model. Regarding physiological function, miRNA-143 and miRNA-145 are very important for general contractility in cerebral vessels in response to depolarization, angiotensin II, and endothelin-1. Applying an anti-miRNA targeting approach in SAH does not seem to be a feasible approach because miRNA-143 and miRNA-145 are not upregulated following SAH. The knockout mouse data suggest that targeting miRNA-143 and miRNA-145 would lead to a general reduced contractility of the cerebral vasculature and unwanted dedifferentiation of VSMCs.

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Biuppslag (personer, institutioner, konferenser, titlar ...)

Johansson, Sara EllinorCopenhagen University Hospital(Swepub:lu)med-soj (författare)
Warfvinge, KarinLund University,Lunds universitet,Medicin/akutsjukvård, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Copenhagen University Hospital(Swepub:lu)oft-kwa (författare)
Braun, ThomasMax Planck Institute for Heart and Lung Research (författare)
Boettger, ThomasMax Planck Institute for Heart and Lung Research (författare)
Edvinsson, LarsLund University,Lunds universitet,Experimentell kärlforskning,Forskargrupper vid Lunds universitet,Experimental Vascular Research,Lund University Research Groups,Copenhagen University Hospital,Skåne University Hospital(Swepub:lu)med-led (författare)
Haanes, Kristian AgmundCopenhagen University Hospital (författare)
Copenhagen University HospitalMedicin/akutsjukvård, Lund (creator_code:org_t)

Sammanhörande titlar

Ingår i:Journal of Cardiovascular Pharmacology74:5, s. 409-4191533-4023

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Journal of Cardiovascular Pharmacology (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Christensen, Sim ...; Johansson, Sara ...; Warfvinge, Karin; Braun, Thomas; Boettger, Thomas; Edvinsson, Lars; visa fler...; Haanes, Kristian ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

Artiklar i publikationen: Journal of Cardi ...

Av lärosätet: Lunds universitet

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