Search: id:"swepub:oai:lup.lub.lu.se:c07cbe47-8d0c-4993-b288-f58e3e17729c" >
Multicenter reprodu...
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Deh, KofiCornell University
(author)
Multicenter reproducibility of quantitative susceptibility mapping in a gadolinium phantom using MEDI+0 automatic zero referencing
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2018-10-04
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Wiley,2019
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8 s.
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LIBRIS-ID:oai:lup.lub.lu.se:c07cbe47-8d0c-4993-b288-f58e3e17729c
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https://lup.lub.lu.se/record/c07cbe47-8d0c-4993-b288-f58e3e17729cURI
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https://doi.org/10.1002/mrm.27410DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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Purpose: To determine the reproducibility of quantitative susceptibility mapping at multiple sites on clinical and preclinical scanners (1.5 T, 3 T, 7 T, and 9.4 T) from different vendors (Siemens, GE, Philips, and Bruker) for standardization of multicenter studies. Methods: Seven phantoms distributed from the core site, each containing 5 compartments with gadolinium solutions with fixed concentrations between 0.625 mM and 10 mM. Multi-echo gradient echo scans were performed at 1.5 T, 3 T, 7 T, and 9.4 T on 12 clinical and 3 preclinical scanners. DICOM images from the scans were processed into quantitative susceptibility maps using the Laplacian boundary value (LBV) and MEDI+0 automatic uniform reference algorithm. Region of interest (ROI) analyses were performed by a physicist to determine agreement between results from all sites. Measurement reproducibility was assessed using regression, Bland-Altman plots, and the intra-class correlation coefficient (ICC). Results: Quantitative susceptibility mapping (QSM) from all scanners had similar, artifact-free visual appearance. Regression analysis showed a linear relationship between gadolinium concentrations and average QSM measurements for all phantoms (y = 350x – 0.0346, r2>0.99). The SD of measurements increased almost linearly from 32 ppb to 230 ppb as the measured susceptibility increased from 0.26 ppm to 3.56 ppm. A Bland-Altman plot showed the bias, upper, and lower limits of agreement for all comparisons were −10, −210, and 200 ppb, respectively. The ICC was 0.991 with a 95% CI (0.973, 0.99). Conclusions: QSM shows excellent multicenter reproducibility for a large range of susceptibility values encountered in cranial and extra-cranial applications on a diverse set of scanner platforms.
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Kawaji, KeigoUniversity of Chicago Medical Center,Illinois Institute of Technology
(author)
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Bulk, MarjoleinLeiden University Medical Centre
(author)
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Van Der Weerd, LouiseLeiden University Medical Centre
(author)
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Lind, EmelieLund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-eli
(author)
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Spincemaille, PascalCornell University
(author)
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McCabe Gillen, KellyCornell University
(author)
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Van Auderkerke, JohanUniversity of Antwerp
(author)
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Wang, YiCornell University
(author)
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Nguyen, Thanh D.Cornell University
(author)
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Cornell UniversityUniversity of Chicago Medical Center
(creator_code:org_t)
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In:Magnetic Resonance in Medicine: Wiley81:2, s. 1229-12360740-31941522-2594
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Deh, Kofi
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Kawaji, Keigo
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Bulk, Marjolein
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Van Der Weerd, L ...
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Lind, Emelie
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Spincemaille, Pa ...
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McCabe Gillen, K ...
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Wang, Yi
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Nguyen, Thanh D.
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