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  • Deh, KofiCornell University (author)

Multicenter reproducibility of quantitative susceptibility mapping in a gadolinium phantom using MEDI+0 automatic zero referencing

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2018-10-04
  • Wiley,2019
  • 8 s.

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  • LIBRIS-ID:oai:lup.lub.lu.se:c07cbe47-8d0c-4993-b288-f58e3e17729c
  • https://lup.lub.lu.se/record/c07cbe47-8d0c-4993-b288-f58e3e17729cURI
  • https://doi.org/10.1002/mrm.27410DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Purpose: To determine the reproducibility of quantitative susceptibility mapping at multiple sites on clinical and preclinical scanners (1.5 T, 3 T, 7 T, and 9.4 T) from different vendors (Siemens, GE, Philips, and Bruker) for standardization of multicenter studies. Methods: Seven phantoms distributed from the core site, each containing 5 compartments with gadolinium solutions with fixed concentrations between 0.625 mM and 10 mM. Multi-echo gradient echo scans were performed at 1.5 T, 3 T, 7 T, and 9.4 T on 12 clinical and 3 preclinical scanners. DICOM images from the scans were processed into quantitative susceptibility maps using the Laplacian boundary value (LBV) and MEDI+0 automatic uniform reference algorithm. Region of interest (ROI) analyses were performed by a physicist to determine agreement between results from all sites. Measurement reproducibility was assessed using regression, Bland-Altman plots, and the intra-class correlation coefficient (ICC). Results: Quantitative susceptibility mapping (QSM) from all scanners had similar, artifact-free visual appearance. Regression analysis showed a linear relationship between gadolinium concentrations and average QSM measurements for all phantoms (y = 350x – 0.0346, r2>0.99). The SD of measurements increased almost linearly from 32 ppb to 230 ppb as the measured susceptibility increased from 0.26 ppm to 3.56 ppm. A Bland-Altman plot showed the bias, upper, and lower limits of agreement for all comparisons were −10, −210, and 200 ppb, respectively. The ICC was 0.991 with a 95% CI (0.973, 0.99). Conclusions: QSM shows excellent multicenter reproducibility for a large range of susceptibility values encountered in cranial and extra-cranial applications on a diverse set of scanner platforms.

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  • Kawaji, KeigoUniversity of Chicago Medical Center,Illinois Institute of Technology (author)
  • Bulk, MarjoleinLeiden University Medical Centre (author)
  • Van Der Weerd, LouiseLeiden University Medical Centre (author)
  • Lind, EmelieLund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-eli (author)
  • Spincemaille, PascalCornell University (author)
  • McCabe Gillen, KellyCornell University (author)
  • Van Auderkerke, JohanUniversity of Antwerp (author)
  • Wang, YiCornell University (author)
  • Nguyen, Thanh D.Cornell University (author)
  • Cornell UniversityUniversity of Chicago Medical Center (creator_code:org_t)

Related titles

  • In:Magnetic Resonance in Medicine: Wiley81:2, s. 1229-12360740-31941522-2594

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