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Prospective Study o...
Prospective Study on Metabolic Factors and Risk of Prostate Cancer
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- Häggstrom, Christel (författare)
- Umeå universitet,Urologi och andrologi
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- Stocks, Tanja (författare)
- Umeå universitet,Umeå University,Urologi och andrologi
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- Ulmert, David (författare)
- Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups,Lund Univ, Skåne Univ Hosp, Dept Clin Sci, Malmö, Sweden
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- Bjorge, Tone (författare)
- Univ Bergen, Dept Publ Hlth & Primary Hlth Care, Bergen, Norway
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- Ulmer, Hanno (författare)
- nnsbruck Med Univ, Dept Med Stat Informat & Hlth Econ, Innsbruck, Austria
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- Hallmans, Göran (författare)
- Umeå universitet,Enheten för biobanksforskning,Näringsforskning
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- Manjer, Jonas (författare)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Lund Univ, Dept Plast Surg, Skåne Univ Hosp, Malmö, Sweden
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- Engeland, Anders (författare)
- Univ Bergen, Dept Publ Hlth & Primary Hlth Care, Bergen, Norway
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- Nagel, Gabriele (författare)
- Univ Ulm, Inst Epidemiol & Med Biometry, Ulm, Germany
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- Almqvist, Martin (författare)
- Lund Univ, Skåne Univ Hosp, Dept Surg, Malmö, Sweden
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- Selmer, Randi (författare)
- Norwegian Inst Publ Hlth, Oslo, Norway
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- Concin, Hans (författare)
- Agcy Prevent & Social Med, Bregenz, Austria
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- Tretli, Steinar (författare)
- Canc Registry Norway, Inst Populat Based Canc Res, Oslo, Norway
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- Jonsson, Håkan (författare)
- Umeå universitet,Onkologi
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- Stattin, Pär (författare)
- Umeå universitet,Urologi och andrologi
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(creator_code:org_t)
- 2012-10-22
- 2012
- Engelska.
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Ingår i: Cancer. - : Wiley. - 1097-0142 .- 0008-543X. ; 118:24, s. 6199-6206
- Relaterad länk:
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http://dx.doi.org/10...
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https://onlinelibrar...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: There are inconsistent data regarding the association between metabolic factors, separately and combined, and the risk of prostate cancer and death from prostate cancer. METHODS: In the Metabolic Syndrome and Cancer Project (Me-Can), data on body mass index (BMI); blood pressure; and blood levels of glucose, cholesterol, and triglycerides were collected for 289,866 men. Cox proportional hazard models were used to calculate relative risks (RRs) by exposures in quintiles as well as for z scores (with a mean of 0 and a standard deviation of 1) together with a composite sum of scores to assess the combined effect of metabolic factors. RRs were corrected for random errors in measurement. RESULTS: During a mean follow-up of 12 years, 6673 men were diagnosed with prostate cancer and 961 died of the disease. Men with high levels of glucose and triglycerides were found to have a decreased risk of prostate cancer: top versus bottom quintile of glucose: RR, 0.82 (95% confidence interval [95% CI], 0.62-1.08; P value for trend = .03) and top versus bottom quintile of triglycerides: RR, 0.88 (95% CI, 0.74-1.04; P value for trend = .001). High BMI, elevated blood pressure, and a high composite z score were found to be associated with an increased risk of death from prostate cancer: top versus bottom quintile of BMI: RR, 1.36 (95% CI, 1.08-1.71); systolic blood pressure: RR, 1.62 (95% CI, 1.07-2.45); and per 1-unit increase of the composite z score: RR, 1.13 (95% CI, 1.03-1.25). CONCLUSIONS: The authors found no evidence of an association between high levels of metabolic factors and the risk of prostate cancer, but high BMI, elevated blood pressure, and a composite score of all metabolic factors were associated with an increased risk of death from prostate cancer. Cancer 2012;118:6199-206. (C) 2012 American Cancer Society.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- epidemiology
- metabolic factors
- prostate cancer
- metabolic syndrome
- cohort study
- body mass index
- blood pressure
- epidemiology
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
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Cancer
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Häggstrom, Chris ...
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Stocks, Tanja
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Ulmert, David
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Bjorge, Tone
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Ulmer, Hanno
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Hallmans, Göran
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Manjer, Jonas
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Engeland, Anders
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Nagel, Gabriele
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Almqvist, Martin
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Selmer, Randi
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Concin, Hans
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Tretli, Steinar
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Jonsson, Håkan
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Stattin, Pär
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