Sökning: (WFRF:(Groop Leif)) srt2:(2010-2014) >
SNP in the genome-w...
-
Fagerholm, E.
(författare)
SNP in the genome-wide association study hotspot on chromosome 9p21 confers susceptibility to diabetic nephropathy in type 1 diabetes
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
-
2012-05-29
-
Springer Science and Business Media LLC,2012
Nummerbeteckningar
-
LIBRIS-ID:oai:lup.lub.lu.se:c0c2b51f-83c1-4945-bbdf-260d4629bf12
-
https://lup.lub.lu.se/record/3055685URI
-
https://doi.org/10.1007/s00125-012-2587-0DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:art swepub-publicationtype
-
Ämneskategori:ref swepub-contenttype
Anmärkningar
-
Parental type 2 diabetes mellitus increases the risk of diabetic nephropathy in offspring with type 1 diabetes mellitus. Several single nucleotide polymorphisms (SNPs) that predispose to type 2 diabetes mellitus have recently been identified. It is, however, not known whether such SNPs also confer susceptibility to diabetic nephropathy in patients with type 1 diabetes mellitus. We genotyped nine SNPs associated with type 2 diabetes mellitus in genome-wide association studies in the Finnish population, and tested for their association with diabetic nephropathy as well as with severe retinopathy and cardiovascular disease in 2,963 patients with type 1 diabetes mellitus. Replication of significant SNPs was sought in 2,980 patients from three other cohorts. In the discovery cohort, rs10811661 near gene CDKN2A/B was associated with diabetic nephropathy. The association remained after robust Bonferroni correction for the total number of tests performed in this study (OR 1.33 [95% CI 1.14, 1.56], p = 0.00045, p (36tests) = 0.016). In the meta-analysis, the combined result for diabetic nephropathy was significant, with a fixed effects p value of 0.011 (OR 1.15 [95% CI 1.02, 1.29]). The association was particularly strong when patients with end-stage renal disease were compared with controls (OR 1.35 [95% CI 1.13, 1.60], p = 0.00038). The same SNP was also associated with severe retinopathy (OR 1.37 [95% CI 1.10, 1.69] p = 0.0040), but the association did not remain after Bonferroni correction (p (36tests) = 0.14). None of the other selected SNPs was associated with nephropathy, severe retinopathy or cardiovascular disease. A SNP predisposing to type 2 diabetes mellitus, rs10811661 near CDKN2A/B, is associated with diabetic nephropathy in patients with type 1 diabetes mellitus.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Ahlqvist, EmmaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)infl-eah
(författare)
-
Forsblom, C.
(författare)
-
Sandholm, N.
(författare)
-
Syreeni, A.
(författare)
-
Parkkonen, M.
(författare)
-
McKnight, A. J.
(författare)
-
Tarnow, L.
(författare)
-
Maxwell, A. P.
(författare)
-
Parving, H. -H.
(författare)
-
Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr
(författare)
-
Groop, P. -H.
(författare)
-
Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Diabetologia: Springer Science and Business Media LLC55:9, s. 2386-23931432-04280012-186X
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Fagerholm, E.
-
Ahlqvist, Emma
-
Forsblom, C.
-
Sandholm, N.
-
Syreeni, A.
-
Parkkonen, M.
-
visa fler...
-
McKnight, A. J.
-
Tarnow, L.
-
Maxwell, A. P.
-
Parving, H. -H.
-
Groop, Leif
-
Groop, P. -H.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
Diabetologia
- Av lärosätet
-
Lunds universitet