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Search: WFRF:(Hofvind Solveig) > (2015-2019) > An independent poor...

  • Tekpli, XavierOslo university hospital (author)

An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-12-03
  • Springer Science and Business Media LLC,2019

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:c0c58bba-96c8-4eb4-a0aa-8a6b569b3e82
  • https://lup.lub.lu.se/record/c0c58bba-96c8-4eb4-a0aa-8a6b569b3e82URI
  • https://doi.org/10.1038/s41467-019-13329-5DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • How mixtures of immune cells associate with cancer cell phenotype and affect pathogenesis is still unclear. In 15 breast cancer gene expression datasets, we invariably identify three clusters of patients with gradual levels of immune infiltration. The intermediate immune infiltration cluster (Cluster B) is associated with a worse prognosis independently of known clinicopathological features. Furthermore, immune clusters are associated with response to neoadjuvant chemotherapy. In silico dissection of the immune contexture of the clusters identified Cluster A as immune cold, Cluster C as immune hot while Cluster B has a pro-tumorigenic immune infiltration. Through phenotypical analysis, we find epithelial mesenchymal transition and proliferation associated with the immune clusters and mutually exclusive in breast cancers. Here, we describe immune clusters which improve the prognostic accuracy of immune contexture in breast cancer. Our discovery of a novel independent prognostic factor in breast cancer highlights a correlation between tumor phenotype and immune contexture.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Lien, TonjeOslo university hospital (author)
  • Røssevold, Andreas HagenOslo university hospital (author)
  • Nebdal, DanielOslo university hospital (author)
  • Borgen, ElinOslo university hospital (author)
  • Ohnstad, Hege OmaOslo university hospital (author)
  • Kyte, Jon AmundOslo university hospital (author)
  • Vallon-Christersson, JohanLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-jvc (author)
  • Fongaard, MarieOslo university hospital (author)
  • Due, Eldri UndlienOslo university hospital (author)
  • Svartdal, Lisa GregussonOslo university hospital (author)
  • Sveli, My Anh TuOslo university hospital (author)
  • Garred, ØysteinOslo university hospital (author)
  • Børresen-Dale, Anne LiseOslo university hospital (author)
  • Schlichting, EllenOslo university hospital (author)
  • Sauer, TorillAkershus University Hospital,University of Oslo (author)
  • Geisler, JürgenAkershus University Hospital,University of Oslo (author)
  • Hofvind, SolveigOslo Metropolitan University,Cancer Registry of Norway, Institute of Population-Based Cancer Research (author)
  • Bathen, Tone F.Norwegian University of Science and Technology (author)
  • Engebråten, OlavOslo university hospital,University of Oslo (author)
  • Geitvik, Gry AarumOslo university hospital (author)
  • Langerød, AnitaOslo university hospital (author)
  • Kåresen, RolfOslo university hospital,University of Oslo (author)
  • Mælandsmo, Gunhild MariUiT The Arctic University of Norway, Tromsø,Oslo university hospital (author)
  • Lingjærde, Ole ChristianUniversity of Oslo (author)
  • Skjerven, Helle Kristine (author)
  • Park, Daehoon (author)
  • Fritzman, Britt (author)
  • Frigessi, ArnoldoUniversity of Oslo (author)
  • Sahlberg, Kristine KleiviOslo university hospital (author)
  • Sørlie, ThereseOslo university hospital (author)
  • Russnes, Hege G.Oslo university hospital (author)
  • Naume, BjørnOslo university hospital,University of Oslo (author)
  • Kristensen, Vessela N.Oslo university hospital,Akershus University Hospital (author)
  • Oslo university hospitalBröstcancer-genetik (creator_code:org_t)
  • OSBREAC

Related titles

  • In:Nature Communications: Springer Science and Business Media LLC10:12041-1723

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