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Stress and circulat...
Stress and circulating cell-free mitochondrial DNA : A systematic review of human studies, physiological considerations, and technical recommendations
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- Trumpff, Caroline (författare)
- Columbia University
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- Michelson, Jeremy (författare)
- Columbia University
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- Lagranha, Claudia J. (författare)
- University of Pittsburgh
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- Taleon, Veronica (författare)
- Columbia University
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- Karan, Kalpita R. (författare)
- Columbia University
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- Sturm, Gabriel (författare)
- Columbia University
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- Lindqvist, Daniel (författare)
- Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Enheten för Biologisk Psykiatri och Precisionspsykiatri,Forskargrupper vid Lunds universitet,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Unit for Biological and Precision Psychiatry,Lund University Research Groups,Region Skåne
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- Fernström, Johan (författare)
- Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Enheten för Biologisk Psykiatri och Precisionspsykiatri,Forskargrupper vid Lunds universitet,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Unit for Biological and Precision Psychiatry,Lund University Research Groups
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- Moser, Dirk (författare)
- Ruhr-University Bochum
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- Kaufman, Brett A. (författare)
- University of Pittsburgh
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- Picard, Martin (författare)
- New York State Psychiatric Institute,Columbia University
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- Engelska 21 s.
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Ingår i: Mitochondrion. - : Elsevier BV. - 1567-7249. ; 59, s. 225-245
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Cell-free mitochondrial DNA (cf-mtDNA) is a marker of inflammatory disease and a predictor of mortality, but little is known about cf-mtDNA in relation to psychobiology. A systematic review of the literature reveals that blood cf-mtDNA varies in response to common real-world stressors including psychopathology, acute psychological stress, and exercise. Moreover, cf-mtDNA is inducible within minutes and exhibits high intra-individual day-to-day variation, highlighting the dynamic regulation of cf-mtDNA levels. We discuss current knowledge on the mechanisms of cf-mtDNA release, its forms of transport (“cell-free” does not mean “membrane-free”), potential physiological functions, putative cellular and neuroendocrine triggers, and factors that may contribute to cf-mtDNA removal from the circulation. A review of in vitro, pre-clinical, and clinical studies shows conflicting results around the dogma that physiological forms of cf-mtDNA are pro-inflammatory, opening the possibility of other physiological functions, including the cell-to-cell transfer of whole mitochondria. Finally, to enhance the reproducibility and biological interpretation of human cf-mtDNA research, we propose guidelines for blood collection, cf-mtDNA isolation, quantification, and reporting standards, which can promote concerted advances by the community. Defining the mechanistic basis for cf-mtDNA signaling is an opportunity to elucidate the role of mitochondria in brain-body interactions and psychopathology.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- cell-free DNA
- Mitochondria
- mtDNA
- Non-inflammatory effects
- Psychosocial stress
- Standard protocol
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Trumpff, Carolin ...
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Michelson, Jerem ...
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Lagranha, Claudi ...
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Taleon, Veronica
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Karan, Kalpita R ...
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Sturm, Gabriel
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visa fler...
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Lindqvist, Danie ...
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Fernström, Johan
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Moser, Dirk
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Kaufman, Brett A ...
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Picard, Martin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Cell och molekyl ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biokemi och mole ...
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Mitochondrion
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Lunds universitet