Decrease in all-cause 30-day mortality after bacteraemia over a 15-year period : A population-based cohort study in Denmark in 2000–2014

Introduction: Bacteraemia is a frequent infectious condition that strongly affects morbidity and mortality. The incidence is increasing worldwide. This study explores all-cause 30-day mortality after bacteraemia in two out of Denmark’s five healthcare regions with approximately 2.4 million inhabitants. Methods: Clinically significant bacteraemia episodes (n = 55,257) were identified from a geographically well-defined background population between 2000 and 2014, drawing on population-based data regarding bacterial species and vital status. All-cause 30-day mortality was assessed in relation to bacteraemia episodes, number of patients with analysed blood cultures and the background population. Results: We observed a decreasing trend of all-cause 30-day mortality between 2000 and 2014, both in relation to the number of bacteraemia episodes and the background population. Mortality decreased from 22.7% of the bacteraemia episodes in 2000 to 17.4% in 2014 (annual IRR [95% CI]: 0.983 [0.979–0.987]). In relation to the background population, there were 41 deaths per 100,000 inhabitants in 2000, decreasing to 39 in 2014 (annual IRR [95% CI]: 0.988 [0.982–0.993]). Numbers of inhabitants, bacteraemia episodes, and analysed persons having BCs increased during the period. Conclusions: All-cause 30-day mortality in patients with bacteraemia decreased significantly over a 15-year period.

Jansåker, FilipLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Copenhagen University Hospital(Swepub:lu)fi6705ja (författare)
Gradel, Kim OrenUniversity of Southern Denmark,Odense University Hospital (författare)
Nielsen, Rikke ThoftDanish Serum Institute, Copenhagen,Hvidovre Hospital (författare)
Østergaard Andersen, ChristianHvidovre Hospital (författare)
Jarløv, Jens OttoGentofte Hospital (författare)
Schønheyder, Henrik CarlAalborg University Hospital,Aalborg University (författare)
Knudsen, Jenny DahlCopenhagen University Hospital (författare)
Hvidovre HospitalAllmänmedicin och klinisk epidemiologi (creator_code:org_t)

Ingår i:International Journal of Environmental Research and Public Health: MDPI AG18:111661-78271660-4601

Av författaren/redakt...: Holm, Mona Katri ...; Jansåker, Filip; Gradel, Kim Oren; Nielsen, Rikke T ...; Østergaard Ander ...; Jarløv, Jens Ott ...; visa fler...; Schønheyder, Hen ...; Knudsen, Jenny D ...; visa färre...

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