Search: WFRF:(Svennelid Fredrik) >
Alterations in regu...
Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice
-
Choi, Young Hun (author)
-
Park, Sunhee (author)
-
Hockman, Steven (author)
-
show more...
-
Zmuda-Trzebiatowska, Emilia (author)
-
- Svennelid, Fredrik (author)
- Lund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
-
Haluzik, Martin (author)
-
Gavrilova, Oksana (author)
-
Ahmad, Faiyaz (author)
-
Pepin, Laurent (author)
-
Napolitano, Maria (author)
-
Taira, Masato (author)
-
- Sundler, Frank (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
-
- Stenson, Lena (author)
- Lund University,Lunds universitet,Signaltransduktionsforskning,Forskargrupper vid Lunds universitet,Insulin Signal Transduction,Lund University Research Groups
-
- Degerman, Eva (author)
- Lund University,Lunds universitet,Signaltransduktionsforskning,Forskargrupper vid Lunds universitet,Insulin Signal Transduction,Lund University Research Groups
-
Manganiello, Vincent C. (author)
-
show less...
-
(creator_code:org_t)
- 2006
- 2006
- English.
-
In: Journal of Clinical Investigation. - 0021-9738. ; 116:12, s. 3240-3251
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Cyclic nucleotide phosphodiesterase 3B (PDE3B) has been suggested to be critical for mediating insulin/IGF-1 inhibition of cAMP signaling in adipocytes, liver, and pancreatic beta cells. In Pde3b-KO adipocytes we found decreased adipocyte size, unchanged insulin-stimulated phosphorylation of protein kinase B and activation of glucose uptake, enhanced catecholamine-stimulated lipolysis and insulin-stimulated hpogenesis, and blocked insulin inhibition of catecholamine-stimulated lipolysis. Glucose, alone or in combination with glucagon-like peptide-1, increased insulin secretion more in isolated pancreatic KO islets, although islet size and morphology and immunoreactive insulin and glucagon levels were unchanged. The beta(3)-adrenergic agonist CL 316,243 (CL) increased lipolysis and serum insulin more in KO mice, but blood glucose reduction was less in CL-treated KO mice. Insulin resistance was observed in KO mice, with liver an important site of alterations in insulin-sensitive glucose production. In KO mice, liver triglyceride and cAMP contents were increased, and the liver content and phosphorylation states of several insulin signaling, gluconeogenic, and inflammation- and stress-related components were altered. Thus, PDE3B may be important in regulating certain cAMP signaling pathways, including lipolysis, insulin-induced antilipolysis, and cAMP-mediated insulin secretion. Altered expression and/or regulation of PDE3B may contribute to metabolic dysregulation, including systemic insulin resistance.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Choi, Young Hun
-
Park, Sunhee
-
Hockman, Steven
-
Zmuda-Trzebiatow ...
-
Svennelid, Fredr ...
-
Haluzik, Martin
-
show more...
-
Gavrilova, Oksan ...
-
Ahmad, Faiyaz
-
Pepin, Laurent
-
Napolitano, Mari ...
-
Taira, Masato
-
Sundler, Frank
-
Stenson, Lena
-
Degerman, Eva
-
Manganiello, Vin ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
- Articles in the publication
-
Journal of Clini ...
- By the university
-
Lund University