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Krebs von den Lunge...
Krebs von den Lungen 6 (KL-6) is a novel diagnostic and prognostic biomarker in pleural mesothelioma
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- Stockhammer, Paul (författare)
- Ruhrlandklinik
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- Baumeister, Hannah (författare)
- Ruhrlandklinik
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- Ploenes, Till (författare)
- Ruhrlandklinik
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visa fler...
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- Bonella, Francesco (författare)
- Ruhrlandklinik
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- Theegarten, Dirk (författare)
- University Hospital Essen
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- Dome, Balazs (författare)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,Medical University of Vienna,Semmelweis University,National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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- Pirker, Christine (författare)
- Medical University of Vienna
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- Berger, Walter (författare)
- Medical University of Vienna
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- Hegedüs, Luca (författare)
- Ruhrlandklinik
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- Baranyi, Marcell (författare)
- Semmelweis University
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- Schuler, Martin (författare)
- University Hospital Essen
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- Deshayes, Sophie (författare)
- University of Nantes
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- Bölükbas, Servet (författare)
- Ruhrlandklinik
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- Aigner, Clemens (författare)
- University Hospital Essen,Ruhrlandklinik
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- Blanquart, Christophe (författare)
- University of Nantes
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- Hegedüs, Balazs (författare)
- Ruhrlandklinik
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Lung Cancer. - 0169-5002. ; 185
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives: Pleural mesothelioma (PM) is a rare disease with dismal outcome. Systemic treatment options include chemotherapy and immunotherapy, but biomarkers for treatment personalization are missing. The only FDA-approved diagnostic biomarker is the soluble mesothelin-related protein (SMRP). Krebs von den Lungen-6 (KL-6) is a human mucin 1 (MUC1) glycoprotein, which has shown diagnostic and prognostic value as a biomarker in other malignancies. The present study investigated whether KL-6 can serve as a diagnostic and/or prognostic biomarker in PM. Materials and methods: Using a fully-automated chemiluminescence enzyme immunoassay (CLEIA) for KL-6 and SMRP, pleural effusion samples from 87 consecutive patients with PM and 25 patients with non-malignant pleural disorders were studied. In addition, KL-6 and SMRP levels were determined in corresponding patient sera, and in an independent validation cohort (n = 122). MUC1 mRNA and protein expression, and KL-6 levels in cell line supernatants were investigated in PM primary cell lines in vitro. Results: PM patients had significantly higher KL-6 levels in pleural effusion than non-malignant controls (AUC 0.78, p < 0.0001). Among PM patients, levels were highest in those with epithelioid or biphasic histologies. There was a strong positive correlation between pleural effusion levels of KL-6 and SMRP (p < 0.0001). KL-6 levels in sera similarly associated with diagnosis of PM, however, to a lesser extent (AUC 0.71, p = 0.008). PM patients with high pleural effusion KL-6 levels (≥303 IU/mL) had significantly better overall survival (OS) compared to those with low KL-6 levels (HR 0.51, p = 0.004). Congruently, high tumor cell MUC1 mRNA expression in primary cell lines associated with prolonged corresponding patient OS (HR 0.35, p = 0.004). These findings were confirmed in an independent validation cohort. Conclusion: This is the first study demonstrating KL-6 as a potential novel liquid-based diagnostic and prognostic biomarker in PM.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Nyckelord
- Biomarker
- KL-6
- Mucins
- Pleural effusion
- Pleural mesothelioma
- SMRP
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Stockhammer, Pau ...
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Baumeister, Hann ...
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Ploenes, Till
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Bonella, Frances ...
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Theegarten, Dirk
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Dome, Balazs
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visa fler...
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Pirker, Christin ...
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Berger, Walter
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Hegedüs, Luca
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Baranyi, Marcell
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Schuler, Martin
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Deshayes, Sophie
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Bölükbas, Servet
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Aigner, Clemens
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Blanquart, Chris ...
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Hegedüs, Balazs
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visa färre...
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Lung Cancer
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Lunds universitet